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This Week in the Lancet Oncology: December 28, 2011


In the Lancet Oncology, Amrita Krishnan at the City of Hope Cancer Center in Los Angeles and her colleagues report their assessment of the effectiveness of allogeneic hemopoietic stem-cell transplants, or HSCT, with non-myeloablative conditioning after autologous HSCT versus tandem autologous HSCT in 710 multiple myeloma patients. The researchers found that "non-myeloablative allogeneic HSCT after autologous HSCT is not more effective than tandem autologous HSCT for patients with standard-risk multiple myeloma," they report.

Medical College of Wisconsin's Mary Eapen led a team of researchers who studied whether matching at HLA C — in addition to typing at HLA A and B and HLA DRB1 — is needed for unrelated umbilical-cord blood transplants. As they report in the Lancet Oncology, the researchers found that the "present strategy for umbilical-cord blood unit selection should be reassessed; matching at HLA C for units that are matched at HLA A, B, or DRB1 or in the presence of a single locus mismatch at HLA A, B, or DRB1 should be included to minimise mortality risks."

Finally, a team led by Anas Younes at the University of Texas MD Anderson Cancer Center reports findings from an open-label, single-arm phase 2 trial, which show that mocetinostat "has promising single-agent clinical activity with manageable toxicity in patients with relapsed classical Hodgkin's lymphoma."

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.