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This Week in the Lancet Oncology: December 28, 2011

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In the Lancet Oncology, Amrita Krishnan at the City of Hope Cancer Center in Los Angeles and her colleagues report their assessment of the effectiveness of allogeneic hemopoietic stem-cell transplants, or HSCT, with non-myeloablative conditioning after autologous HSCT versus tandem autologous HSCT in 710 multiple myeloma patients. The researchers found that "non-myeloablative allogeneic HSCT after autologous HSCT is not more effective than tandem autologous HSCT for patients with standard-risk multiple myeloma," they report.

Medical College of Wisconsin's Mary Eapen led a team of researchers who studied whether matching at HLA C — in addition to typing at HLA A and B and HLA DRB1 — is needed for unrelated umbilical-cord blood transplants. As they report in the Lancet Oncology, the researchers found that the "present strategy for umbilical-cord blood unit selection should be reassessed; matching at HLA C for units that are matched at HLA A, B, or DRB1 or in the presence of a single locus mismatch at HLA A, B, or DRB1 should be included to minimise mortality risks."

Finally, a team led by Anas Younes at the University of Texas MD Anderson Cancer Center reports findings from an open-label, single-arm phase 2 trial, which show that mocetinostat "has promising single-agent clinical activity with manageable toxicity in patients with relapsed classical Hodgkin's lymphoma."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.