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This Week in the Lancet Oncology: December 28, 2011

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In the Lancet Oncology, Amrita Krishnan at the City of Hope Cancer Center in Los Angeles and her colleagues report their assessment of the effectiveness of allogeneic hemopoietic stem-cell transplants, or HSCT, with non-myeloablative conditioning after autologous HSCT versus tandem autologous HSCT in 710 multiple myeloma patients. The researchers found that "non-myeloablative allogeneic HSCT after autologous HSCT is not more effective than tandem autologous HSCT for patients with standard-risk multiple myeloma," they report.

Medical College of Wisconsin's Mary Eapen led a team of researchers who studied whether matching at HLA C — in addition to typing at HLA A and B and HLA DRB1 — is needed for unrelated umbilical-cord blood transplants. As they report in the Lancet Oncology, the researchers found that the "present strategy for umbilical-cord blood unit selection should be reassessed; matching at HLA C for units that are matched at HLA A, B, or DRB1 or in the presence of a single locus mismatch at HLA A, B, or DRB1 should be included to minimise mortality risks."

Finally, a team led by Anas Younes at the University of Texas MD Anderson Cancer Center reports findings from an open-label, single-arm phase 2 trial, which show that mocetinostat "has promising single-agent clinical activity with manageable toxicity in patients with relapsed classical Hodgkin's lymphoma."

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.