This Week in Cancer Discovery

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In Cancer Discovery this week, researchers in the UK and Switzerland report they performed a functional metabolic screen to identify the gene PFKFB4 as an important regulator of prostate cancer cell survival. The team analyzed the effect of silencing 222 different enzymes, transporters, and regulators on the survival of three metastatic prostate cancer cell lines and one non-malignant prostate cancer cell line and found that there are several genes required for the cells' survival.

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In Nature this week: genomic analysis of high-grade serous ovarian cancer, and more.

The new Riken president outlines some of his plans for the institute.

The Guardian discusses whether big science projects are worth the loss of resources available for other scientific pursuits.

An NEJM update from the ClinVar team highlights the difficulties of interpreting genetic variants.