This Week in Cancer Discovery

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In the newest issue of Cancer Discovery, researchers in the US and Spain report on the HIF-1α hypoxia response in tumor-infiltrating T lymphocytes. They found that CD8 and CD4 tumor-infiltrating T lymphocytes from colon carcinomas, melanomas, and spontaneous breast adenocarcinomas transplanted into mice are CD137-positive and that the expression of CD137 on activated T lymphocytes is enhanced by hypoxia and the prolyl-hydroxylase inhibitor dimethyloxalylglycine.

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