In the British Journal of Cancer, researchers from South Korea present a dose-escalation study of the drug irinotecan for patients with advanced gastric cancer, and determine the drug's effect on the UGT1A1 genotype. The team administered increasing doses of irinotecan to 43 patients and sequenced DNA isolate from their peripheral blood to determine their UGT1A1 genotypes. The overall response rate was 9.3 percent, and the disease control rate was 62.8 percent.

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In PNAS this week: Akt3 amplification in glioma progression, Tibetan Plateau frog genome, and more.

The US Supreme Court has declined to review a decision involving the use of "inadvertently shed" DNA in a police investigation and subsequent conviction.

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National Institutes of Health Director Francis Collins appears before a House subcommittee to discuss his agency's budget request.