In the British Journal of Cancer this week, researchers in the UK report that NT5E is epigenetically regulated in patients with malignant melanoma. The team analyzed the expression and regulation of NT5E in malignant melanoma cell lines, and in samples of primary and metastatic melanomas, and found that the gene is subject to epigenetic regulation in the disease. It is down-regulated by methylation-dependent transcriptional silencing in several cell lines, the team writes.

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In Science this week: mtDNA analysis give glimpse into decline of Neanderthals in Europe, and more.

The University of Arizona's Raina Maier writes that an understanding of the Earth's microbiome is needed.

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