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Unwanted Effects


A new study published in Cell shows that attacking cancer cells by inhibiting telomerase can lead to some unwanted side effects, reports MedicalXpress. In tumors, telomerase protects malignant cells from being destroyed, and although it may seem like blocking telomerase would make it easier to kill the cells, this approach also triggers the activation of resistance pathways that allow the cancer to spread, MedicalXpress adds. Using a lymphoma mouse model, the researchers found an unexpected metabolic pathway that cancer cells use to adapt to the loss of telomerase. They add that the eventual re-activation of telomerase in the malignant cells causes cancer progression.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.