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Unwanted Effects


A new study published in Cell shows that attacking cancer cells by inhibiting telomerase can lead to some unwanted side effects, reports MedicalXpress. In tumors, telomerase protects malignant cells from being destroyed, and although it may seem like blocking telomerase would make it easier to kill the cells, this approach also triggers the activation of resistance pathways that allow the cancer to spread, MedicalXpress adds. Using a lymphoma mouse model, the researchers found an unexpected metabolic pathway that cancer cells use to adapt to the loss of telomerase. They add that the eventual re-activation of telomerase in the malignant cells causes cancer progression.

The Scan

Driving Malaria-Carrying Mosquitoes Down

Researchers from the UK and Italy have tested a gene drive for mosquitoes to limit the spread of malaria, NPR reports.

Office Space to Lab Space

The New York Times writes that some empty office spaces are transforming into lab spaces.

Prion Pause to Investigate

Science reports that a moratorium on prion research has been imposed at French public research institutions.

Genome Research Papers on Gut Microbe Antibiotic Response, Single-Cell RNA-Seq Clues to Metabolism, More

In Genome Research this week: gut microbial response to antibiotic treatment, approach to gauge metabolic features from single-cell RNA sequencing, and more.