Journal Study
Reactivated Promoters in Transposable Elements Help Form Unique Tumor Antigens
The finding of tumor-specific cell-surface antigens resulting from TE-chimeric transcripts lays the foundation for developing a pan-cancer vaccine, according to the authors.
Breast Cancer Study Leads to New Susceptibility Gene, Potential Treatment Strategies
Researchers found risk variants in the DNA damage checkpoint gene ATRIP in a Polish founder population and linked the gene to breast cancer risk and HRD in other populations.
Neuroblastoma Outcomes Linked to Tumor Evolution Features, Timeframe
With deep genome sequencing and molecular clock analyses of 186 neuroblastomas, researchers saw ties between longer tumor evolution and more aggressive disease.
Transcriptomic Classification of Pediatric Cancers Shows Potential to Improve Clinical Diagnoses
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In a new paper, computational biologists at Toronto's Hospital for Sick Children described their atlas of childhood cancer subtypes and a corresponding search tool.
International Team Develops New Method to Detect Protein Isoforms in the Human Proteome
The study identified more than 1 million peptides from 17,717 different protein groups from six human cell lines.