Journal Study
Reproduction, Lifespan Show Antagonistic Pleiotropy in Genetic Analysis
Using UK Biobank data, researchers found that genetic variants linked to increased reproductive capabilities coincided with shorter lifespan in individuals of European ancestry.
Organ-Specific Aging Markers Picked Out of Plasma Proteomic Analysis
With these markers, researchers established models for looking at aging across 11 human organs, highlighting ties between accelerated organ aging and disease.
Ovarian Cancer Detected Early With DNA From Pap Smear in Proof-of-Principle Study
Researchers developed an early ovarian cancer test based on DNA from Pap smears from women who went on to develop high-grade serous ovarian cancer.
Type 2 Diabetes Development Linked to GWAS-Informed Regulatory Modules
Researchers used transcriptomic and functional analyses to find regulatory modules for early-stage type 2 diabetes, focusing in on a module containing the beta cell-related gene RFX6.
Coronary Artery Calcification Culprits Uncovered in Sequencing-Based GWAS
With whole-genome sequencing on 22,400 multi-ancestry participants, researchers performed a genome-wide association study leading to a vascular calcification contributor.