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immune response

Population Differences in SARS-CoV-2 Response Uncovered in Single-Cell Sequencing Study

A single-cell analysis suggests immune cell proportions and blood cell expression patterns vary between individuals, across populations, and with exposure to different viruses.

COVID-19 Protection Provided by HLA Genetic Variant, Study Suggests

Using data from bone marrow registry participants, researchers found an HLA variant linked to symptom-free SARS-CoV-2 infection and better immune cell responses.

Transcriptomics Unravels Role of Interferon Receptors in Down's Syndrome

The findings of a transcriptome analysis of blood from 304 individuals with Down's syndrome and 96 controls have implications for therapeutic development.

French Researchers Developing Molecular Test for Endometriosis Diagnosis, Subtyping
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The five-year, EU-funded project, called MensEndoDiag, will explore the use of menstrual blood as a sample type.

Wellcome Sanger's Dandelion Pipeline Updated for Single-Cell Adaptive Immune Receptor Analysis
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The Dandelion bioinformatics method now includes T-cell receptor-based "pseudotime trajectory analysis" to support better understanding of single-cell lymphocyte biology.

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Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.