NEW YORK (GenomeWeb News) – The National Institute of Allergy and Infectious Diseases will fund research projects of up to five years for development of new knowledge and technologies that can be used to study major histocompatibility complex genes in non-human primates (NHPs).
Knowledge gained from studying the MHC in such primates can be valuable for NIAID’s efforts to prevent and treat immunologic, infectious, and allergic diseases, NIAID said in a request for proposals.
The “NHP Major Histocompatibility Complex Gene Discovery and Typing Technology Development Program” is aimed at facilitating and enhancing immunological research using NHP models.
The research should provide detailed knowledge of NHP MHC genes, loci, and alleles through gene discovery and genomic characterization studies.
The studies also could develop and provide readily accessible means or methods to genotype individual research animals for the complete set of MHC alleles, and for select alleles, or for the optimum design of experiments and genetic management colonies.
The NHP research community requires a variety of DNA-based technologies, including methods for specific allele genotyping, haplotyping, and complete MHC genotyping, NIAID said. It also said affordable methods that are easily upgraded as new allelic or haplotype information becomes available are needed, as well as methods that are relatively high-throughput and easily translated to labs involved in NHP research.
For these programs, development and accessibility to high-throughput technologies for MHC allele genotyping and/or haplotype determination are required to accelerate immunological studies in NHP species.