whole-genome sequencing

Researchers found that hypoxia was associated with elevated genomic instability in 10 tumor types and saw widespread hypoxia-associated dysregulation of miRNAs.

NorthShore University HealthSystem is among the first of many interested in implementing genetic testing and tracking the population health impact, according to Color.

Investigators analyzed the inactivation of tumor suppressor genes and its transcriptional consequences in thousands of tumors from 33 cancer types or subtypes.

The company also said it will release its first polygenic risk score for cardiovascular disease early this year.

Using real-time nanopore metagenomic sequencing, researchers ruled out enhanced human-to-human transmission of Lassa virus during an outbreak in Nigeria last year.

DNA sequence data from hundreds of individuals suggest that age, smoking, and alcohol use coincide with the expansion of clones containing NOTCH1 and PPM1D mutations.

Australian researchers sequenced ancient and modern Aboriginal Australians to find long-term population continuity, which could help return remains to proper groups.

This Week in Nature

In Nature this week: genomic analysis of the invasive fall webworm, amp of constrained coding regions within the human genome, and more.

This Week in PLOS

In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.

While the New York Genome Center says whole-genome cancer sequencing is the future, companies already offering such tests are struggling to get paid.

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Researchers are refining a tool to predict a woman's risk of developing breast cancer, according to the Guardian.

According to Stat News, the partial government shutdown in the US could soon affect the ability of the Food and Drug Administration to review new drugs.

In PNAS this week: gypsy moth genome sequenced, phylogenomic analysis of Polyneopterans, and more.

CNN reports that people's genes tend to have a greater influence on their risk of developing disease than their environment, but it varies by phenotype.