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whole-genome sequencing

With plasmid and chromosomal sequence data, European investigators identified three main routes for carbapenem antibiotic resistance spread in Klebsiella pneumoniae.

Interim results from a study in the Netherlands suggest whole-genome sequencing can be done fast enough to uncover treatment targets in metastatic cancer patients.

The company's approach combines whole-genome sequencing, CRISPR, liquid biopsy, and gene therapy to target cancer cells with gene fusions.

Researchers studied the genetic structure of Viking Age Scandinavian populations, along with migrations and the adoption of Viking culture by non-Scandinavians.

By combining genome sequence data with phylogenetics and other clues, two teams looked at the SARS-CoV-2 introductions that sparked outbreaks in North America and Europe.

Driving the shift is a belief that standard STR testing is not always a reliable tool for determining complex family relationships.

A pilot study enrolling up to 15 patients will validate CapeDx's utility to match patients to approved drugs and clinical trials based on whole-genome and tumor sequencing.

Researchers from MedGenome, Genentech, and multiple international institutions found potentially actionable alterations in more than 200 gallbladder cancer samples.

Using sequence data from nearly 2,500 isolates submitted to GISAID before April, researchers tallied coding and non-coding changes in the virus across locations and conditions.

The sequence-based analysis suggests oncogene-containing circular, extrachromosomal sequences occur in most cancer types and may correspond with poorer patient outcomes.

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Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

Vox reports that the Trump Administration may limit student visas for individuals from some countries to two years.

The governor of New York says the state will conduct its own review of any SARS-CoV-2 vaccine, NPR reports.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.