whole-genome sequencing Mutational Signatures Profiled in Pediatric Cancers Researchers uncovered and analyzed mutational signatures in 27 cancer types or subtypes by analyzing genome sequences for nearly 800 tumors. Sarcoma Susceptibility Traced to Telomere Function, Mitotic Pathways A search for rare sarcoma-related germline variants led to centromere and shelterin genes involved in mitotic function and telomere regulation, respectively. Sequencing Study Uncovers Genes Under Positive Selection in Large, Long-Lived Sea Creatures Sequences from a range of cetacean species suggest the aquatic environment has exerted selective pressure genes involved in growth, cancer suppression, and other features. Plague Pathogen Population History Informed by Integrative Analysis Researchers found that genetic analyses of Yersinia pestis genomes alone could not sufficiently track the slow-mutating microbes, which have an unstable molecular clock. Rebranded GeneDx Bets Future on Whole-Exome, Whole-Genome Sequencing in Pediatric Rare Disease Premium After dropping underdeveloped Sema4 business lines but emphasizing the Centrellis informatics platform, the new GeneDx expects to reach profitability by 2025. Jan 11, 2023 Cancer Detection Method Developed From DNA Fragment Patterns, Ends Jan 9, 2023 Illumina, Nashville Biosciences Ink WGS Agreement With Amgen for African American Cohort Jan 5, 2023 Ancient Genomes Reveal Scandinavian Population History Dec 30, 2022 Esophageal Cancer Molecular Study Highlights Tumor Subtypes, Treatment Response Markers Dec 19, 2022 SeekIn Receives CE-IVD Mark for Leukemia Cancer Mutation Detection Kit Dec 16, 2022 Study Finds Genetic Roots of Brown Coloring in Black Bears Dec 16, 2022 Computational Tool Tracks Genetic Variation Effects of Off-Target Gene Editing Dec 15, 2022 Late-Onset Ataxia Linked to New Repeat Expansion in FGF14 Gene Dec 14, 2022 Cancer Genome Analysis Unearths Potentially Targetable Tandem Repeat Expansions Dec 12, 2022 Genomic Biopharma Partners With Italian Patient Advocacy Group to Offer Whole-Genome Sequencing Dec 8, 2022 Denisovan DNA Detected in Papuan Immune Gene Regulatory Regions Dec 6, 2022 Pacific Biosciences, Boston Children's Hospital to Collaborate on Rare Disease Variant Pilot Project Dec 1, 2022 Study Unearths Features Found in Long-Term Survivors of Advanced Ovarian Cancer Nov 16, 2022 Genome Insight, Seoul National University Hospital Collaborate on WGS Study of Pediatric Cancer Dx Nov 11, 2022 Clear Labs Pushing Automated Whole-Genome Sequencing Into Clinical Market for Infection Control Premium Nov 9, 2022 Dante Genomics, Al Farabi Medical Laboratories Partner on NGS-Based Testing in Saudi Arabia Nov 3, 2022 Meta-Analyses Hint at Severe COVID-19 Risk Factors, Ties to Autoimmune Disease Nov 2, 2022 Longenesis, Dante Genomics Partner to Offer Whole-Genome Sequencing for Women’s Health in Europe Oct 31, 2022 SeqFirst Results Highlight Diagnostic Gains From Rapid Genome Sequencing in Critically Ill Newborns Premium Oct 26, 2022 Single-Cell Sequencing Reveals Breast, Ovarian Cancer-Related Mutational Processes Load More Breaking News New Products Posted to GenomeWeb: Qiagen, Thermo Fisher, Bionano Genomics, BillionToOne, More People in the News at Illumina Ventures, Element Biosciences, Epigenomics, Exagen, More Genomic Approaches Boost Rare Disease Diagnoses in Middle Eastern Patient Population GeneDx to Raise $150M in Public and Direct Stock Offerings In Brief This Week: T2 Biosystems, Novacyt, OpGen, Dante Genomics, Nautilus Biotechnology, More The Scan Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups. Genome-Wide Analysis Sheds Light on Genetics of ADHD A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder. MicroRNA Cotargeting Linked to Lupus A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus. Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.