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transposon sequencing

Reactivated Promoters in Transposable Elements Help Form Unique Tumor Antigens

The finding of tumor-specific cell-surface antigens resulting from TE-chimeric transcripts lays the foundation for developing a pan-cancer vaccine, according to the authors.

Mnemo Therapeutics Identifies Possible New Class of Cancer Therapeutic Target
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The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells.

Developmental Disorder Study Uncovers Cases Marked by Mobile Genetic Element Insertions

Thousands of parent-child exomes helped researchers identify apparently causative mobile element insertions in a handful of children with developmental disorders.

Human Malaria Parasite Mutagenesis Highlights Essential Genes, Potential Drug Targets

Saturation mutagenesis of the human malaria parasite Plasmodium falciparum identified almost 2,700 essential genes during the blood stage of infection.

Sleeping Beauty Insertion Sequencing Method Applied to Search for Blood Cancer Drivers
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Researchers applied an unbiased transposon mutagenesis sequencing method called SBCapSeq to assess heterogeneity and driver mutations in a mouse model for myeloid leukemia.

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.