transposon sequencing
Reactivated Promoters in Transposable Elements Help Form Unique Tumor Antigens
The finding of tumor-specific cell-surface antigens resulting from TE-chimeric transcripts lays the foundation for developing a pan-cancer vaccine, according to the authors.
The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells.
Developmental Disorder Study Uncovers Cases Marked by Mobile Genetic Element Insertions
Thousands of parent-child exomes helped researchers identify apparently causative mobile element insertions in a handful of children with developmental disorders.
Human Malaria Parasite Mutagenesis Highlights Essential Genes, Potential Drug Targets
Saturation mutagenesis of the human malaria parasite Plasmodium falciparum identified almost 2,700 essential genes during the blood stage of infection.
Researchers applied an unbiased transposon mutagenesis sequencing method called SBCapSeq to assess heterogeneity and driver mutations in a mouse model for myeloid leukemia.