transcriptomics

Genome and transcriptome sequences from hundreds of pediatric cancer cases led to somatic mutations and fusions suspected of producing potentially targetable antigens.

Researchers from Hong Kong imputed transcriptomes from GWAS data and compared them to drug-induced gene expression profiles.

The researchers observed that eliminating these microsatellite repeat expansion RNAs in patient cells reversed some hallmark features of the diseases.

As part of their MI-ONCOSEQ Program, Michigan researchers examined the mutational and transcriptional landscape of 500 metastatic tumors.

RNA sequencing of patient-derived fibroblasts was able to provide 10 percent of patients with a diagnosis after whole-exome sequencing had failed.

Researchers saw partial overlap between variants influencing age-related methylation and neuronal patterns and those implicated in other traits or diseases.