Genome and transcriptome sequences from hundreds of pediatric cancer cases led to somatic mutations and fusions suspected of producing potentially targetable antigens.
In Science this week: database of proteins' effects on cancer, targeted error correction sequencing, and more.
Researchers from Hong Kong imputed transcriptomes from GWAS data and compared them to drug-induced gene expression profiles.
The researchers observed that eliminating these microsatellite repeat expansion RNAs in patient cells reversed some hallmark features of the diseases.
As part of their MI-ONCOSEQ Program, Michigan researchers examined the mutational and transcriptional landscape of 500 metastatic tumors.
Participants tried to classify samples based on the epigenomic impact of cigarette smoke cessation and aerosol from modified- or reduced-risk products.
RNA sequencing of patient-derived fibroblasts was able to provide 10 percent of patients with a diagnosis after whole-exome sequencing had failed.
In Genome Research this week: esophageal adenocarcinoma sequencing study, the automated BLAST pipeline Leapfrog, and more.
Researchers saw partial overlap between variants influencing age-related methylation and neuronal patterns and those implicated in other traits or diseases.
In Genome Research this week: repetitive satellite DNA in the fruit fly, transcriptome map assembly pipeline, and more.
Sequencing could help combat foodborne illnesses, according to a blog post by Food and Drug Administration officials.
Popular Mechanics reports that Caltech researchers have built a prototype nanobot using DNA.
The Sacramento Bee writes that direct-to-consumer genetic testing connected a woman to sperm donor-conceived half siblings.
In PLOS this week: gene expression catalog for sheep, viral diversity among respiratory samples from camels, and more.