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Dec 05, 2019

High-Throughput Single-Cell Transcriptomics Assay Facilitates Compound Screens

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The new method, called sci-Plex, combines nuclear hashing and improved single-cell combinatorial indexing RNA-seq to profile the transcriptional response of single cells.

Nov 25, 2019

Alzheimer's Disease Gene Expression Varies by Brain Cell Type

Using a single-nucleus RNA sequencing strategy, investigators tracked down cell type-specific gene expression and networks in Alzheimer's brains.

Nov 20, 2019

Nucleic Acids Research Papers on FIN-Seq, ChlamDB, BBCancer

In Nucleic Acids Research this week: sequencing strategy for flash-frozen brain tissue bank samples, new version of ChlamDB, and more.

Nov 13, 2019

Cell Studies Assess Hepatocellular Carcinoma Immune Cells, Renal Cell Carcinoma, More

In Cell this week: analysis of immune microenvironment in hepatocellular carcinoma, proteogenomic analysis of clear cell renal cell carcinoma, and more.

Nov 12, 2019

Supercentenarians Have Increased Levels of Cytotoxic CD4 T Cells

A single-cell transcriptome study found increased numbers of cytotoxic CD4 T cells, which could be an adaptation to the later stages of aging.

Nov 11, 2019

10x Genomics' Fully Automated Single-Cell Library Prep Platform Coming in Early 2020

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The Chromium Connect, designed for pharma workflows and other high-volume customers, is one of several products coming out of 10x's R&D pipeline.

Nov 11, 2019

PLOS Papers Look at Gut Mycobacterium Abscessus, Preterm Birth Transcriptomics, More

In PLOS this week: Mycobacterium abscessus linked to gastric conditions, placental gene expression changes associated with preterm birth, and more.

Oct 23, 2019

Nucleic Acids Research Studies Describe Cell Viability Signature, Han Chinese Genome Database, More

In Nucleic Acids Research this week: ways to find cell death or proliferation signatures, Han Chinese population genome database, and more.

Oct 14, 2019

Novigenix, RadioMedix to Develop Neuroendocrine Cancer MDx

The companies will develop an assay to guide treatment with a type of radiopharmaceutical therapy in patients with these rare tumors.

Oct 09, 2019

Single-Cell Transcriptome Atlas Gives Peek at Cell Interactions in Liver Cirrhosis

The researchers molecularly characterized cells found in cirrhotic tissue that express genes involved in pro-fibrogenic pathways that could be targeted by drugs.

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The Scan

That Rude Reviewer

ScienceInsider reports that rude and unprofessional paper reviewers are common and can have harmful effects.

New FDA Commish Confirmed

The US Senate has confirmed Stephen Hahn as the next commissioner of the Food and Drug Administration, according to the New York Times.

DNA Screening for Apple Employees

CNBC reports Apple is partnering with Color Genomics to offer its employees free DNA screening for disease.

Science Studies Describe Role for Microbiome-Derived Immunity, Platform to Develop Flavivirus Vaccines

In Science this week: researchers use CRISPR tool to find gut microbiome molecules involved in immunity, and more.

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