This Week in Cell

In Cell this week: sequencing to understand medulloblastoma metastases, genome and transcriptome implicates TAP1 in X-linked Dystonia-Parkinsonism, and more.

Two new analyses have identified driver genes, altered pathways, mutational signatures, and other molecular features across two dozen cancer subtypes.

An international team of researchers analyzed the transcriptomes of post-mortem tissue samples to find transcriptional changes.

Using post-mortem data, researchers explored similarities and differences between autism, schizophrenia, bipolar disorder, alcoholism, and depression.

As organisms age, their transcriptomic signatures shift from looking more like those observed in cancer to those seen in degenerative chronic diseases.

A La Jolla Institute for Allergy and Immunology-led team sequenced the transcriptomes of thousands of CD4+ T cells and compared their expression patterns.

The most significant update to the Connectivity Map since its 2006 founding offers a low-cost way to analyze most RNA transcriptomes.

Researchers are exploring the genetics of Christmas trees to make them more durable, according to Wired.

Homologous recombination deficiency predicted with the HRDetect tool corresponded to favorable breast cancer outcomes after platinum-based chemotherapy.

In Genome Research this week: regulatory variation in human induced pluripotent stem cells, sparse isoform sequencing, and more.


An opinion piece in the Guardian argues that President Donald Trump is uninterested in science and that might not be a bad thing for the field.

The San Francisco Chronicle reports the Veterans Affairs Health System is studying whether genetic testing can help prescribe better depression therapies.

Stat News reports that Spark Therapeutics' Luxturna is now being used to treat a wider array of patients.

In Genome Biology this week: transcription factor use among brittle stars, single-cell RNA sequencing strategy, and more.