top-down proteomics Northwestern Team's Top-Down Mass Spec Approach Can Analyze 1K Single Cells per Day Premium While the method is still in its early stages, it points the way toward a very high-throughput workflow for top-down single-cell proteomics. Proteomics Researchers Aim to Improve Analyses of Peptide-Level Data Premium The aim is to improve the accuracy of the protein measurements commonly reported as the output of proteomic experiments and uncover obscured biological signals. Top Down Proteomics Identifies Protein-Level Effects of KRAS Mutations in Colorectal Cancer Premium The study used analysis of intact proteins to identify mutation-linked post-translational modifications involved in KRAS activation and membrane attachment. Genentech Scientists Offer Perspective on Proteomics' Evolution Into General Research Tool Premium Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research. Northwestern's Kelleher Awarded $7.5M Grant to Advance Top-Down Proteomics Premium The effort, dubbed the National Resource for Translational and Developmental Proteomics, aims to improve on the technology and train others in its use. Apr 10, 2015 Northwestern Team Develops System for Simplifying Sample Cleanup in Top-Down Proteomics Premium Mar 23, 2015 Young Investigator Profile: Sangtae Kim May 31, 2013 PNNL Top-Down Study IDs 1600-plus Salmonella Proteoforms Including Previously Undetected PTM Premium Oct 26, 2012 Q&A: Neil Kelleher on his Proposal for a Cell-Based Human Proteome Project Premium Mar 23, 2012 Q&A: Jonathan Sweedler on the Challenges and Opportunities for Peptidomics Premium Jun 11, 2009 New Technology Combining Bruker's MALDI-TOF/TOF with Bio-Rad's SELDI Set to Launch Premium Breaking News Genetic Contributors to Plasma Protein Levels Unearthed in Multiple Studies Standard BioTools, SomaLogic to Merge Arima Genomics, Protean BioDiagnostics Launch 3D Genomics Cancer Testing Joint Venture Pathnostics UTI Test Nabs New York State Approval NanoString, A*Star, Next Level Genomics to Launch Spatial Biology Laboratory in Singapore The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.