top-down proteomics Proteomics Researchers Aim to Improve Analyses of Peptide-Level Data Premium The aim is to improve the accuracy of the protein measurements commonly reported as the output of proteomic experiments and uncover obscured biological signals. Top Down Proteomics Identifies Protein-Level Effects of KRAS Mutations in Colorectal Cancer Premium The study used analysis of intact proteins to identify mutation-linked post-translational modifications involved in KRAS activation and membrane attachment. Genentech Scientists Offer Perspective on Proteomics' Evolution Into General Research Tool Premium Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research. Northwestern's Kelleher Awarded $7.5M Grant to Advance Top-Down Proteomics Premium The effort, dubbed the National Resource for Translational and Developmental Proteomics, aims to improve on the technology and train others in its use. Northwestern Team Develops System for Simplifying Sample Cleanup in Top-Down Proteomics Premium According to the researchers, the system could make top-down approaches more widely shareable as well as improve their applicability to clinical work. Mar 23, 2015 Young Investigator Profile: Sangtae Kim May 31, 2013 PNNL Top-Down Study IDs 1600-plus Salmonella Proteoforms Including Previously Undetected PTM Premium Oct 26, 2012 Q&A: Neil Kelleher on his Proposal for a Cell-Based Human Proteome Project Premium Mar 23, 2012 Q&A: Jonathan Sweedler on the Challenges and Opportunities for Peptidomics Premium Jun 11, 2009 New Technology Combining Bruker's MALDI-TOF/TOF with Bio-Rad's SELDI Set to Launch Premium Breaking News Lunaphore Technologies, University of Bern Partner on Colorectal Cancer Study People in the News: New Appointments at Biocept, Novacyt, Centogene, Illumina, More In Brief This Week: Sophia Genetics, Twist Bioscience, Dante Labs, MGI, Codex DNA, More New Products Posted to GenomeWeb: SpeeDx, Bio-Techne, NuProbe, More DiaSorin Q2 Revenues Rise 20 Percent on SARS-CoV-2 Testing Demand Cepheid Gets $28M From BARDA for SARS-CoV-2 Tests The Scan Interfering With Invasive Mussels The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels. Participation Analysis A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports. Right Whales' Decline A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC. Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.