top-down proteomics
The controls are meant to restrict the access of certain countries — most notably China — to mass spec technology the government said could be put to military use.
US Government Places Export Controls on LC-MS Instruments for Top-Down Proteomics
The government did not specify which platforms would be covered by the rule but said countries are using LCMS technology to develop military capabilities.
Researchers including Northwestern's Neil Kelleher and UVA's Gloria Sheynkman are exploring whether the platform could complement their mass spec analyses.
While the method is still in its early stages, it points the way toward a very high-throughput workflow for top-down single-cell proteomics.
The aim is to improve the accuracy of the protein measurements commonly reported as the output of proteomic experiments and uncover obscured biological signals.