top-down proteomics

The study used analysis of intact proteins to identify mutation-linked post-translational modifications involved in KRAS activation and membrane attachment.

Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research.

The effort, dubbed the National Resource for Translational and Developmental Proteomics, aims to improve on the technology and train others in its use.

According to the researchers, the system could make top-down approaches more widely shareable as well as improve their applicability to clinical work.

Pacific Northwest National Laboratory's Sangtae Kim is taking on the challenges of analyzing top-down proteomic data.

A team led by researchers at Pacific Northwest National Laboratory has devised a streamlined top-down proteomics approach that they have used to profile the pathogen Salmonella Typhimurium.

Name: Neil Kelleher
Position: Professor of Molecular Biosciences, Chemistry, and Medicine, Northwestern University
Background: PhD, Cornell University; Associate Professor, University of Illinois at Urbana-Champaign

The system, called Lucid Proteomics, combining Bio-Rad's SELDI-based array technology with Bruker's ultrafleXtreme MALDI-TOF/TOF instrument, is expected to hit the market in late summer or early fall, and is the first fruit of a co-marketing and co-development collaboration between the two firms announced a month ago.

In a statement, National Institutes of Health Director Francis Collins says sexual harassment is "morally indefensible" and "unacceptable."

Octopuses might owe their intelligence to their liberal alterations to their genes, Cosmos reports.

Stat News and ProPublica report that African Americans are underrepresented in cancer clinical trials.

In Cell this week: genomic analysis of abdominal aortic aneurysm, effect of probiotics on the microbiome, and more.