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siRNA

The program is designed to support the collection and analysis of "informative molecular activity and cellular feature signatures" in response to siRNAs, small molecules, and other perturbing agents in a variety of cell types.

Although Quark initially expects to market the drug as a treatment for a rare condition known as non-arteritic anterior ischemic optic neuropathy, it hopes it can eventually develop it as a glaucoma treatment.

Alnylam previously released data from a phase IIa study of the drug in RSV-infected adult lung transplant patients showing that it was safe and well tolerated. While the data indicated a certain level of efficacy, this demonstration was less robust than many industry watchers had expected.

The designation allows for possible research and development incentives, and qualifies the company for tax credits and a period of market exclusivity following market approval.

The patent describes the modulation of claudins, which are proteins associated with tumor progression and metastasis.

The company's core technology is dubbed PRINT, or Pattern Replication In Non-wetting Templates. It involves making templates of specific patterns, on which a proprietary non-stick polymer is applied to create a mold.

The collaboration will focus on Bioo's Targeted Transport Technology, which involves joining a carrier agent to a monoclonal antibody to produce a conjugate that is then loaded with an RNAi molecule such as an siRNA or miRNA mimic, to deliver anti-HIV siRNAs into T cells.

The Council for Scientific and Industrial Research has become a member of Thermo Fisher's RNAi Global Initiative.

The deal will allow Koken to manufacture and sell siRNA research products covered by certain of Alnylam's RNAi-related intellectual property.

While few details about the plaintiff in the case, PSN Illinois, were available, court filings indicate that the company has initiated numerous and varied patent-infringement suits in recent years.

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A letter criticizing actions by the US government and research institutions toward Chinese and Chinese-American scientists has garnered more than a hundred signatories.

NPR reports that researchers in New York are investigating whether it is possible to edit the genomes of human sperm.

In an opinion piece at the Nation, Sarah Lawrence College's Laura Hercher argues that everyone should be able to access prenatal genetic testing.

In Nature this week: ancient DNA uncovers presence of Mediterranean migrants at a Himalayan lake, and more.