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siRNA

Last week, EGEN said it had extended a collaboration with SurModics to develop a controlled-release system for siRNA delivery. As with its other programs, the company plans to let the delivery route determine the indications it pursues.

The technology is covered by 42 issued or allowed patents and 31 pending patent applications worldwide, according to Marina.

The partnership is expected to yield its first IND by 2012.

The combined grants are worth nearly $650,000 and are meant to support work on treatments for cancer and Huntington's disease.

The study is being conducted in Portugal, Sweden, and the UK and will enroll about 28 patients with the disease.

The drug targets adrenergic receptor beta-2 and is delivered topically to the eye.

Doing so, however, will require the company to secure additional funding, and it is currently evaluating its options, a company official said.

The provisions for the EU orphan designation provide incentives to companies developing orphan drugs, including the potential for up to 10 years of market exclusivity and various fee reductions for certain regulatory activities, Quark said.

The deal marks the latest move by RXi to expand its access to new delivery approaches, and may offer some clues as to the therapeutic course RXi is setting for itself, which it will disclose at an investor conference this week.

Among the findings from the ongoing study was the suggestion of an anti-VEGF effect in the majority of treated patients.

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The Washington Post reports that a Russian Academy of Sciences commission has led to the retraction of hundreds of scientific papers.

The Los Angeles Times' Daily Pilot reports the chief executive of Vantari Genetics has pleaded guilty in a kickback scheme.

News 4 Jax reports that a Florida bill to prevent life and long-term care insurers from using genetic information in their coverage decisions has easily passed one committee.

In Science this week: potentially pathogenic mutations found in hematopoietic stem cells from young healthy donors, and more.