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siRNA

Reconstituted HDL nanoparticles were loaded with siRNAs against two key cancer genes and administered intravenously into orthotopic mouse models of cancer, and were able to effectively silence the expression of their targets.

Cenix Joins EU siRNA Consortium

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Cenix jumped on board after one-time member Novosom dropped out following the sale of its liposome-based delivery technology to Marina Biotech last year.

The presentation will focus on data from an ongoing phase I study with Atu027 in subjects with advanced solid cancer. “Key findings presented will include safety, tolerability and pharmacokinetic data, as well as indications of anti-tumor activity,” Silence said.

The study identified 27 genes that might impact colon cancer patients' response to oxaliplatin, a finding that could help Genomic Health add a treatment benefit indication to its Oncotype DX test.

The company said it will use the funds to advance new siRNA delivery compounds and add 10 new researchers and lab technicians.

The company plans to use the funding to enhance its R&D resources and to hire new researchers and lab technicians.

The phase I drug, ALN-VSP02, comprises two siRNAs, one targeting vascular endothelial growth factor and one targeting kinesin spindle protein, both of which the firm said are critical for the growth and survival of cancer cells.

The drug, STP705, uses a polymeric nanoparticle to enhance topical delivery of siRNAs targeting the TGF-beta 1 and Cox-2 genes to open wounds, Sirnaomics said.

Alnylam said that opponents to the patent included Merck subsidiary Sirna Therapeutics, Silence Therapeutics, Pfizer, and BASF.

Notably, the patent in dispute is part of the so-called Zamore IP family. Alnylam's top official earlier this year publicly dismissed a related US patent from the Zamore family as "not worth anything."

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In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.