single-molecule sequencing
The firm's long-read, single-molecule nanopore sequencer promises low cost and high accuracy for low-throughput applications in research and diagnostics.
DAF-seq utilizes a nonspecific deaminase to stencil protein occupancy in individual chromatin fibers and is sensitive enough to be used in single cells.
Recent advancements in long-read sequencing are enabling researchers to study full-length mRNA isoforms at the single-cell level.
The most recent software, Paraphase, produces "mini haplotypes" rather than counting copy number variations to identify variants linked to rare diseases.
SMS-seq combines structural probing with direct RNA nanopore sequencing, offering researchers a new way to study RNA structure at the single-molecule level.