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single-molecule barcoding

This Week in Science

In Science this week: transcriptional regulation of the inflammasome NLRP3, and more.

The lawsuit comes a few days after a jury awarded Bio-Rad Laboratories $23.9 million in damages in a patent infringement suit against 10x Genomics.

The amplicon sequencing method, called resistance mutation sequencing (RM-seq), may help in detecting resistance earlier than traditional techniques.

The startup's first product will focus on 16S and 18S rRNA sequencing, and it plans to launch kits for shotgun metagenomics, HLA sequencing and phasing, and more.

In 2015, the iBOL project met its initial milestone of generating barcode sequences for 500,000 animal, plant, and fungal species.

The researchers have filed a patent on their method, SiMSen-seq, and are continuing to develop it, as well as a software tool, for oncology applications. 

The QIAseq panels, which are available now, are the first of three major product launches Qiagen has planned for the second half of the year.

In early experiments, the method's raw single pass error rate was approximately 2 percent for a single target and up to 4 percent for a mixture of 10 targets. 

The firm is nearing a market launch of the system, called the nanoAnalyzer 1000. The system is being developed for a variety of applications including genome assembly, structural variation analysis, and assessing DNA damage.

A Danish and Swedish-led research team reports that it has used a combination of nanochannels and denaturation to map so-called "barcode" patterns for labeled DNA.

Matt Hancock, the UK health secretary, is calling for the swift rollout of predictive genetic tests, the Guardian reports.

A WHO panel is calling for a global registry of human germline gene-editing projects, according to Stat News.

Vox writes that lab mishaps involving pathogens are quite common.

In Genome Biology this week: analysis of wild and cultivated peach genomes, Hi-C-based pipeline for assembling microbial genomes from metagenomic data, and more.