single molecule barcoding

The team's Pro-Code system enabled simultaneous high-dimensional protein-level phenotyping of hundreds of genes with single-cell resolution.

The companies will work on applying barcoding technology to single-cell measurements of gene and protein expression and to immune cell profiling.

By using array-synthesized guide-donor oligonucleotide pairs, the team's gene editing technique allows accurate and detectable phenotyping in yeast cells.

The team plans to eventually implement the MSI test clinically to determine whether patients are eligible for immunotherapy.

The planned instrument will help provide spatial information on both protein and RNA in tumor samples and will be powered by nCounter technology.

The chemistry will be single-molecule, based on hybridization, and will not require amplification, enzymes, or library prep, the firm said.

The company launched the BD FACSseq flow cytometer and BD Precise Assays for high-throughput single-cell gene-expression analysis studies at the ASHG annual meeting.

The solutions will combine RainDance's digital droplet technology and single-molecule barcoding technology with PacBio's proprietary long-range DNA amplification technology.

NEW YORK (GenomeWeb News) – A federal court has ruled in Illumina's favor in a lawsuit filed by Helicos BioSciences that had alleged patent infringement.

William Young said the firm's platform — which uses digital barcoding to enable multiplexed, direct profiling of individual molecules in a single reaction without amplification — is currently deployed for research purposes, but he sees a big opportunity in diagnostics and pharmacogenomics.

Chinese state news agency Xinhua reports that a preliminary investigation has found He Jiankui performed his gene-editing work illegally.

John Mendelsohn, a former president of the University of Texas MD Anderson Cancer Center, has died, the New York Times reports.

Identical twins receive different estimates of ancestry from the same direct-to-consumer genetic testing firms, CBC reports.

In PNAS this week: chromosomal features of maize, adaptations in the vinous-throated parrotbill, and more.