The LIANTI method uses linear amplification to reduce biases and could have utility in preimplantation genetic screening to detect sub-chromosomal alterations.
A method called genome architecture mapping, or GAM, brings together deep DNA sequencing and laser microdissected slices of individuals cells in a tissue sample.
The two teams used combinatorial indexing for Hi-C and whole-genome sequencing and said that the methods could be tailored for other sequencing applications.
The method allows analysis of copy number at the individual cell level with greater coverage uniformity and more reliable detection than other approaches.
In Science this week: a survey indicates that US adults are more likely to support the agricultural use of gene drives if they target non-native species and if they are limited, and more.
