Research groups from the Broad Institute and the University of Washington have developed protocols to sequence RNA from large numbers of single nuclei and single cells.
Investigators are searching for non-invasive biomarkers of rejection and earlier stage graft injury in children and adults who have received kidney transplants.
The group has filed a patent on the method and is interested in teaming up with an industry partner to commercialize it.
The researchers plan to profile patients with both Adaptive Biotechnologies' ImmunoSeq platform and 10x Genomics' single-cell immune repertoire profiling technology.
With growing interest in single-cell sequencing, researchers are looking to increase the throughput while also reducing cost.
In Nature this week: 90 ancient Egyptian mitochondrial genomes analyzed, and more.
These cell subtypes could help researchers gain a clearer understanding of cell mechanics and find better targets for potential therapies.
The LIANTI method uses linear amplification to reduce biases and could have utility in preimplantation genetic screening to detect sub-chromosomal alterations.
The Harvard spinout is commercializing inDrop single-cell sequencing technology developed by Allon Klein.
In Science this week: sequencing study of IDH glioma origins, and more.
At a meeting this week, researchers and others discussed the regulatory oversight needed for germline genome editing.
The US Food and Drug Administration has asked questions about Myriad Genetics' GeneSight test, according to Bloomberg.
Researchers report that neutrophil extracellular traps appear to binds gallstones together, according to New Scientist.
In Science this week: approach to infer genotype-by-environment interaction from genetic variants associated with phenotypic variability, and more.