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single-cell sequencing

Broad Institute researchers performed RNA-sequencing of 53,000 individual mouse gut epithelial cells to develop and examine expression signatures.

In Genome Biology this week: trait-related gene expression in maize, single-cell RNA sequencing of intracellular bacteria and their hosts, and more.

Such an atlas could enable investigators to understand how genetic variants impact disease risk, define drug toxicities, improve therapies, and advance regenerative medicine.

The startup is launching an instrument that will process up to 10,000 single cells for DNA sequencing as well as a panel that will target AML genes. 

A new set of papers reveals a range of gene expression influencers, identified using thousands of samples collected for the Genotype-Tissue Expression project.

The researchers plan to evaluate cfDNA and single cells isolated from the urine of patients who have had kidney transplants to identify signs of graft failure.

In Science this week: ancient Neanderthal and human genomes, and more.

In Genome Biology this week: computational approach for analyzing noisy single-cell sequencing profiles, eQTLs of dilated cardiomyopathy, and more.

In Science this week: neutrophils rely on microRNA to protect against lung inflammation, and more.

The system uses microfluidics and real-time image analysis to isolate single cells and provide visual documentation of monoclonality.

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The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.