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single-cell sequencing

The competition, part of a $7 million "Grand Challenges" program that Life Tech launched last year, will award a $1 million prize to the first SOLiD user who succeeds in sequencing the genome and transcriptome of a single cancer cell.

There are two main problems when it comes to sequencing single cells: Whole-genome amplification protocols do not amplify the genome in an unbiased manner, and PCR steps in library preparation introduce additional biases and errors.

By sequencing individual cells from primary and metastatic breast cancer samples and using this data to glean copy number patterns in the cells, researchers have gained insights into how these cancers evolved and spread.

Researchers from Cold Spring Harbor Laboratory reported at last week's Biology of Genomes meeting that they sequenced 100 cells from a basal-like breast cancer tumor to reveal five major subpopulations of cells, three of which were cancerous.

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Researchers are developing a breath test to determine how severe patients' methylmalonic acidemia disease is, FierceBiotech reports.

NPR reports that vaccine developers are working on SARS-CoV-2 vaccines that are easier to store or administer than the current crop.

Reuters reports that France is to recommend that people under 55 who received one dose of AstraZeneca's SARS-CoV-2 vaccine receive a different vaccine for their second dose.