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single-cell sequencing

By Monica Heger

This article was originally published April 2.

By Monica Heger

This article was originally published March 19.

By Monica Heger
Despite the technical challenges of single-cell sequencing, researchers have begun using the technique to better study single bacterial species from metagenomic samples.

The competition, part of a $7 million "Grand Challenges" program that Life Tech launched last year, will award a $1 million prize to the first SOLiD user who succeeds in sequencing the genome and transcriptome of a single cancer cell.

There are two main problems when it comes to sequencing single cells: Whole-genome amplification protocols do not amplify the genome in an unbiased manner, and PCR steps in library preparation introduce additional biases and errors.

By sequencing individual cells from primary and metastatic breast cancer samples and using this data to glean copy number patterns in the cells, researchers have gained insights into how these cancers evolved and spread.

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In a letter, about two dozen researchers criticize the World Health Organization investigation into the origins of SARS-CoV-2 and call for a new inquiry, the Wall Street Journal reports.

National Geographic reports that nine great apes at the San Diego Zoo have been vaccinated against SARS-CoV-2.

Janet Woodcock, the acting commissioner of the US Food and Drug Administration, speaks with NPR about SARS-CoV-2 testing and vaccines in the US.

In Science this week: genetic study of kidney fibrosis implicates the SOX9-NAV3-YAP1 axis.