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single-cell sequencing

The competition, part of a $7 million "Grand Challenges" program that Life Tech launched last year, will award a $1 million prize to the first SOLiD user who succeeds in sequencing the genome and transcriptome of a single cancer cell.

There are two main problems when it comes to sequencing single cells: Whole-genome amplification protocols do not amplify the genome in an unbiased manner, and PCR steps in library preparation introduce additional biases and errors.

By sequencing individual cells from primary and metastatic breast cancer samples and using this data to glean copy number patterns in the cells, researchers have gained insights into how these cancers evolved and spread.

Researchers from Cold Spring Harbor Laboratory reported at last week's Biology of Genomes meeting that they sequenced 100 cells from a basal-like breast cancer tumor to reveal five major subpopulations of cells, three of which were cancerous.

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The Washington Post writes that the approval in the US of a SARS-CoV-2 vaccine will be up to Peter Marks, a career official at the Food and Drug Administration.

According to ScienceInsider, the US National Academies of Science, Engineering, and Medicine is planning a study of racism in academic research.

NPR reports the US loan to Eastman Kodak to boost domestic pharmaceutical production is on pause following insider trading allegations.

In Cell this week: blood immune cell changes in COVID-19 patients and spatial transcriptomics in Alzheimer's disease.