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single-cell sequencing

With growing interest in single-cell sequencing, researchers are looking to increase the throughput while also reducing cost.

In Nature this week: 90 ancient Egyptian mitochondrial genomes analyzed, and more.

These cell subtypes could help researchers gain a clearer understanding of cell mechanics and find better targets for potential therapies.

The LIANTI method uses linear amplification to reduce biases and could have utility in preimplantation genetic screening to detect sub-chromosomal alterations.

The Harvard spinout is commercializing inDrop single-cell sequencing technology developed by Allon Klein.

In Science this week: sequencing study of IDH glioma origins, and more.

A method called genome architecture mapping, or GAM, brings together deep DNA sequencing and laser microdissected slices of individuals cells in a tissue sample.

In an AGBT presentation, one early-access user of BD's Resolve platform described how he used it to analyze gene expression from 1,200 kidney cells. 

The two teams used combinatorial indexing for Hi-C and whole-genome sequencing and said that the methods could be tailored for other sequencing applications.

The two new single-cell RNA-sequencing methods aim to overcome some of the limitations of single-cell transcriptomics.

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The Hastings Center's Erik Parens argues in a Scientific American opinion piece that the current pandemic underscores the need to reconsider the hope placed in genomic medicine. 

The Los Angeles Times writes that Operation Warp Speed has an ambitious timeline for developing a COVID-19 vaccine.

The Sydney Morning Herald reports that Australia is launching its trial of preconception carrier testing Tuesday.

In PNAS this week: autosomal genes commonly affected by loss-of-function variants, variants implicated in testis development disorders, and more.