A method called genome architecture mapping, or GAM, brings together deep DNA sequencing and laser microdissected slices of individuals cells in a tissue sample.
In an AGBT presentation, one early-access user of BD's Resolve platform described how he used it to analyze gene expression from 1,200 kidney cells.
The two teams used combinatorial indexing for Hi-C and whole-genome sequencing and said that the methods could be tailored for other sequencing applications.
The two new single-cell RNA-sequencing methods aim to overcome some of the limitations of single-cell transcriptomics.
Systems will ship in early February and include droplet-based library prep and analytics functionalities.
The method allows analysis of copy number at the individual cell level with greater coverage uniformity and more reliable detection than other approaches.
Aviv Regev and Jonathan Weissman have jumped into the single-cell RNA-sequencing, pooled CRISPR screen fray.
The partners will collaborate in developing Atreca's single-cell sequencing technology to advance new cancer immunotherapies.
An international team of researchers reported that disseminated tumor cells likely arise late in tumor development.
The single-cell approach enabled them to identify gene expression in rare cell types, highlighting a previously unrecognized role for these cells in diabetes.
At the Lancet, more than two dozen public health researchers condemn the conspiracy theories that have emerged surrounding the source of the COVID-19 outbreak.
The Washington Post reports that Philip Leder, who helped uncover how DNA codes for proteins and studied the role of genes in cancer, has died.
Researchers from Trinity College Dublin and the University of Pittsburgh look into how often de novo genes arise and how important they may be.
In Nucleic Acids Research this week: pipeline for genotyping Alu retrotransposon mobile element insertions, previously undocumented non-coding RNAs, and more.