single-cell sequencing

This Week in Science

In Science this week: series of reviews about gene modification, and more.

Axolotl

Using single-cell RNA sequencing and reporter lineage tracking, researchers delved into the cellular and molecular processes of axolotl limb regeneration.

The firm aims to launch the new assay in the first quarter of next year and plans to develop other products for single-cell sequencing library prep.

The group plans to use the method to analyze isoform differences of B cell surface receptors, common targets for immunotherapy.

The RNA-seq data, for nearly 40,000 cells from the developing mouse brain, can be explored through an interactive online interface called Cell Seek.

In Genome Research this week: queen bee chromatin profiles, quantitative trait loci and allele-specific expression in wild house mice, and more.

The researchers say that methods that include gene expression as well as other genomic data in one assay could help unravel cell function and gene regulation.

10x plans to use Epinomics' epigenomic technology to launch a single-cell ATAC solution on its Chromium platform by the end of the year.

The SCN3A gene, which encodes a voltage-gate sodium channel in the brain, also controls oral motor development, including swallowing, tongue movement, and speech.

By sequencing 72,501 individual kidney cells, researchers saw some shared transcriptional patterns in kidney cancers and developing or adult kidneys.

Pages

Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.