single-cell sequencing

With growing interest in single-cell sequencing, researchers are looking to increase the throughput while also reducing cost.

The LIANTI method uses linear amplification to reduce biases and could have utility in preimplantation genetic screening to detect sub-chromosomal alterations.

A method called genome architecture mapping, or GAM, brings together deep DNA sequencing and laser microdissected slices of individuals cells in a tissue sample.

In an AGBT presentation, one early-access user of BD's Resolve platform described how he used it to analyze gene expression from 1,200 kidney cells. 

The two teams used combinatorial indexing for Hi-C and whole-genome sequencing and said that the methods could be tailored for other sequencing applications.