single-cell gene expression analysis

Researchers identified immune activity changes in first-trimester placenta and decidua samples profiled through single-cell RNA sequencing.

OMI researchers will apply and validate 1CellBio's inDrop system to generate predictive data for patients with undiagnosed immune dysfunction conditions. 

Using a mouse model of immunotherapy resistant disease, the researchers found that this program could be targeted by an inhibitor to improve response.

Customers can explore public data for free but will need to pay to visualize private data or to obtain additional functionality like real-time cell-type predictions.

Researchers from Belgium analyzed the transcriptomes of almost 100,000 single cells from lung cancer patients, most of them stromal cells.

Two new studies have uncovered expression-defined T cell subsets that seem to coincide with better or worse outcomes in breast cancer or non-small cell lung cancer.

The BigSCale tool incorporates a numerical model that integrates data processing, clustering, convoluting, and differential expression analysis.

This Week in Science

In Science this week: single-cell sequencing to study zebrafish and frog embryonic development.

Three new studies have used single-cell RNA sequencing methods to follow cell type trajectories over the course of zebrafish and Western claw-toed frog development.

The single approach could be useful in some of the same areas where combinations of technologies have been implemented, such as AR-V7 testing in prostate cancer.

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The United Nations is to consider a ban on field testing gene drives at a meeting being held next week, Technology Review reports.

The Associated Press reports that gene-edited food may soon be for sale.

The US Department of Health and Human Services is beginning a series of meetings on human fetal tissue research, Stat News reports.

In Cell this week: epigenetic change linked to glioblastomas, rare and low-frequency variants contributing to multiple sclerosis risk, and more.