single-cell gene expression analysis
Type 2 Diabetes Development Linked to GWAS-Informed Regulatory Modules
Researchers used transcriptomic and functional analyses to find regulatory modules for early-stage type 2 diabetes, focusing in on a module containing the beta cell-related gene RFX6.
Germline Mutagenesis Traced Back to Meiotic Breaks, Error-Prone Repair
By mapping mutations in relation to recombination hotspots, researchers revealed mutagenic effects of meiotic DNA breaks and error-prone repair mechanisms.
Cervical Cancer Multiomic Study Uncovers Informative Intratumor Heterogeneity States
With single-cell, spatial, and experimental approaches, researchers defined eight "meta-programs" linked to the tumor immune microenvironment and clinical features.
Teams Track Embryo-Wide Development With Single-Cell Transcriptomic Strategies
Researchers used single-cell RNA sequencing and other methods for the large-scale phenotyping of wild type and genetically altered mouse and zebrafish embryos.
The method, based on the protocol set by Aviv Regev, is a step toward enabling more genome-wide, rather than targeted, genetic perturbation screens.