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single-cell analysis

In PNAS this week: optical mapping allows glimpse of structural variants, disease-linked GATA2 mutations boosts its protein activity, and more.

Using a microfluidics-based single-cell isoform RNA-seq approach, researchers clustered cerebellar cells and saw isoforms with cell type-specific expression.

Berkeley Lights markets the Beacon platform — a light-based nanofluidics platform for single-cell selection, characterization, culture, and export.

This Tabula Muris could enable discovery of new cell types, detection of novel gene expression in known cells, and comparison of cell types across organs.

Cells that express genes linked to greater proliferation potential are more likely to downregulate the HIV provirus, according to a new study.

With RNA sequence, expression quantitative trait locus, genome-wide association, and other data, researchers identified disease-related genes in the kidney glomerulus and tubule compartments.

In Science this week: series of reviews about gene modification, and more.

HuBMAP is not anticipated to map the entire body, but to provide a framework for more complete mapping and make data available to the research community.

Nucleosome organization appears to follow two principles, according to the researchers' analyses of three different cell types.

Using a new machine-learning approach, researchers from the Sanford Burnham Prebys Medical Discovery Institute analyzed brain cells obtained from mice during neurogenesis.

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A new analysis finds that nearly half the late-stage clinical trials sponsored by a US National Cancer Institute program influence patient care.

Technology Review reports that sickle cell patients are optimistic about gene editing to treat their disease, but are worried about how available it will be.

The owner of the GEDmatch website tells CBS12 he is considering charging law enforcement a fee to use the site.

In Nature this week: babies born by caesarean section are more likely to have altered gut microbiota profiles, and more.