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single-cell analysis

At the Association of Biomolecular Research Facilities annual meeting this week, the ABRF Genomics Research Group presented results from its comparison of single-cell RNA sequencing platforms.

The study found that resistant clones in triple-negative breast tumors existed prior to chemo, but transcriptional changes happened in response to therapy.

In Nucleic Acids Research this week: tool for examining transcription factor-DNA binding intensities, algorithm for classifying metagenomic sequence data, and more.

The single approach could be useful in some of the same areas where combinations of technologies have been implemented, such as AR-V7 testing in prostate cancer.

Independent teams used ScarTrace and MAP-seq to follow cell type development in zebrafish and characterize axonal projections in the mouse visual cortex, respectively.

Researchers have done single-cell RNA sequencing on hundreds of Plasmodium falciparum or P. berghei isolates to track gene activity involved in infection cycles.

In Genome Biology this week: transcription factor use among brittle stars, single-cell RNA sequencing strategy, and more.

In Genome Research this week: guide RNAs to target KRAS mutations, modeling organ development from single cells, and more.

The firm plans to integrate its technology with a compatible microfluidic sample prep method developed by researchers at Columbia University.

The companies will use Berkeley Lights' technology to improve Pfizer's monoclonal antibody discovery and gene editing workflows.

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The former commissioner of the FDA has returned to the venture capital firm New Enterprise Associates as a special partner on the healthcare investment team.

Astronauts have edited yeast genes on the International Space Station in an experiment designed to show how cells repair themselves in space.

Emory University has found that two of its researchers failed to divulge they had received funds from China, according to the Atlanta Journal-Constitution.

In Science this week: influence of the nuclear genome on human mitochondrial DNA, and more.