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single-cell analysis

The effort, outlined in a Development Cell paper published online today, aims to complement the ongoing Human Cell Atlas initiative, but with a focus on pediatric health.

The planned product would combine RNA assays for NanoString's GeoMx digital spatial profiling instrument with Bio-Techne's RNAscope imaging reagents.

With single-cell genome sequencing, recombination assays, and other approaches in mouse cells, researchers identified factors affecting DNA crossover.

In Genome Biology this week: analysis of wild and cultivated peach genomes, Hi-C-based pipeline for assembling microbial genomes from metagenomic data, and more.

The SciLifeLab spinout uses barcoded probes, in situ rolling circle amplification, and sequencing by ligation to measure expression of a panel of genes.

With single-cell RNA-seq on thousands of cells from the lateral hypothalamic area of male and female mice, researchers saw dozens of glutamatergic and GABAergic neuron types.

Analyzing mutational signatures in cancer cell lines and xenografts, investigators identified mutagenic processes that do or don't remain active in vitro.

In Cell this week: somatic mtDNA mutation-based "genetic barcode" method, molecular mechanisms behind structural variants at 17p11.2, and more.

Researchers defined six malignant cell clusters with single-cell transcriptomes and genotypes for thousands of acute myeloid leukemia cells.

In Genome Biology this week: post-transcriptional modification-based stratification of glioblastoma, single-cell analysis of gene expression and methylation in human iPSCs, and more.

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A South African university has told the Wellcome Sanger Institute to return DNA samples it has from indigenous African communities, The Times reports.

The University of California, Berkeley's Rasmus Nielsen and Xinzhu Wei have retracted their CCR5 gene paper due to a technical artifact.

 

University of Virginia researchers are exploring a genetic risk test to gauge type 1 diabetes risk, NPR reports.

In PNAS this week: researchers compare two high-grade neuroendocrine lung cancers, height among ancient Europeans, and more.