The researchers reported that targeting HDAC4 in the patient-derived neurons appeared to correct the expression of genes that differed in the disease state.
Researchers identified immune activity changes in first-trimester placenta and decidua samples profiled through single-cell RNA sequencing.
Using a mouse model of immunotherapy resistant disease, the researchers found that this program could be targeted by an inhibitor to improve response.
Researchers identified 133 neuronal and non-neuronal cell types using single-cell RNA-seq data for tens of thousands of cells from the mouse neocortex.
The platform uses a gravity-based method to capture and isolate up to 100,000 individual cells per run, while maintaining viability and structural integrity.
The researchers found that genes whose transcription in response to an immune challenge diverged across species also varied between single cells.
The team's Pro-Code system enabled simultaneous high-dimensional protein-level phenotyping of hundreds of genes with single-cell resolution.
Using single-cell RNA sequencing and lineage tracing in a mouse model, researchers followed skin stem cell expression patterns in response to skin injury.
In PNAS this week: optical mapping allows glimpse of structural variants, disease-linked GATA2 mutations boosts its protein activity, and more.
Using a microfluidics-based single-cell isoform RNA-seq approach, researchers clustered cerebellar cells and saw isoforms with cell type-specific expression.
The former commissioner of the FDA has returned to the venture capital firm New Enterprise Associates as a special partner on the healthcare investment team.
Astronauts have edited yeast genes on the International Space Station in an experiment designed to show how cells repair themselves in space.
Emory University has found that two of its researchers failed to divulge they had received funds from China, according to the Atlanta Journal-Constitution.
In Science this week: influence of the nuclear genome on human mitochondrial DNA, and more.