Researchers identified immune activity changes in first-trimester placenta and decidua samples profiled through single-cell RNA sequencing.
Using a mouse model of immunotherapy resistant disease, the researchers found that this program could be targeted by an inhibitor to improve response.
Researchers identified 133 neuronal and non-neuronal cell types using single-cell RNA-seq data for tens of thousands of cells from the mouse neocortex.
The platform uses a gravity-based method to capture and isolate up to 100,000 individual cells per run, while maintaining viability and structural integrity.
The researchers found that genes whose transcription in response to an immune challenge diverged across species also varied between single cells.
The team's Pro-Code system enabled simultaneous high-dimensional protein-level phenotyping of hundreds of genes with single-cell resolution.
Using single-cell RNA sequencing and lineage tracing in a mouse model, researchers followed skin stem cell expression patterns in response to skin injury.
In PNAS this week: optical mapping allows glimpse of structural variants, disease-linked GATA2 mutations boosts its protein activity, and more.
Using a microfluidics-based single-cell isoform RNA-seq approach, researchers clustered cerebellar cells and saw isoforms with cell type-specific expression.
Berkeley Lights markets the Beacon platform — a light-based nanofluidics platform for single-cell selection, characterization, culture, and export.
An initial analysis suggests the novel coronavirus from Wuhan that is sickening people might come from snakes, a team of virologists writes at the Conversation.
DNA testing confirms captured Chicago coyote same as the one that bit a boy near a nature museum, the Chicago Tribune reports.
An analysis of Tibetan ice cores uncovers more than two dozen previously unknown virus groups, LiveScience reports.
In Nature this week: genomic analysis of four children buried in Cameroon approximately 3,000 and 8,000 years ago, and more.