single-cell analysis

The study found that resistant clones in triple-negative breast tumors existed prior to chemo, but transcriptional changes happened in response to therapy.

In Nucleic Acids Research this week: tool for examining transcription factor-DNA binding intensities, algorithm for classifying metagenomic sequence data, and more.

The single approach could be useful in some of the same areas where combinations of technologies have been implemented, such as AR-V7 testing in prostate cancer.

Independent teams used ScarTrace and MAP-seq to follow cell type development in zebrafish and characterize axonal projections in the mouse visual cortex, respectively.

Researchers have done single-cell RNA sequencing on hundreds of Plasmodium falciparum or P. berghei isolates to track gene activity involved in infection cycles.

In Genome Biology this week: transcription factor use among brittle stars, single-cell RNA sequencing strategy, and more.

In Genome Research this week: guide RNAs to target KRAS mutations, modeling organ development from single cells, and more.

The firm plans to integrate its technology with a compatible microfluidic sample prep method developed by researchers at Columbia University.

The companies will use Berkeley Lights' technology to improve Pfizer's monoclonal antibody discovery and gene editing workflows.

This Week in Nature

In Nature this week: genome-editing to treat hearing loss in mice, juvenile myelomonocytic leukemia subgroups, and more.

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In an against-all-odds twist, a researcher studying exceeding rare FOXG1 mutations discovers her daughter has the syndrome.

An effort by Genomics Medicine Ireland is creating a database of diseases based on the genomics of people in Ireland. It now is looking into the possibility of including Scotland in its work.

In recent weeks, the direct-to-consumer genetics firm has rolled out a health hub where customers can share information concerning 18 common health conditions.

In PLOS this week, new genes associated with prostate cancer risk, genetic patterns in M. bovis, and more.