single-cell analysis

Researchers identified immune activity changes in first-trimester placenta and decidua samples profiled through single-cell RNA sequencing.

Using a mouse model of immunotherapy resistant disease, the researchers found that this program could be targeted by an inhibitor to improve response.

Researchers identified 133 neuronal and non-neuronal cell types using single-cell RNA-seq data for tens of thousands of cells from the mouse neocortex.

The platform uses a gravity-based method to capture and isolate up to 100,000 individual cells per run, while maintaining viability and structural integrity.

The researchers found that genes whose transcription in response to an immune challenge diverged across species also varied between single cells.

The team's Pro-Code system enabled simultaneous high-dimensional protein-level phenotyping of hundreds of genes with single-cell resolution.

Using single-cell RNA sequencing and lineage tracing in a mouse model, researchers followed skin stem cell expression patterns in response to skin injury.

This Week in PNAS

In PNAS this week: optical mapping allows glimpse of structural variants, disease-linked GATA2 mutations boosts its protein activity, and more.

Using a microfluidics-based single-cell isoform RNA-seq approach, researchers clustered cerebellar cells and saw isoforms with cell type-specific expression.

Berkeley Lights markets the Beacon platform — a light-based nanofluidics platform for single-cell selection, characterization, culture, and export.

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The United Nations is to consider a ban on field testing gene drives at a meeting being held next week, Technology Review reports.

The Associated Press reports that gene-edited food may soon be for sale.

The US Department of Health and Human Services is beginning a series of meetings on human fetal tissue research, Stat News reports.

In Cell this week: epigenetic change linked to glioblastomas, rare and low-frequency variants contributing to multiple sclerosis risk, and more.