Some of the mutational signatures the researchers observed were similar to ones previously seen in B cell tumors, underscoring the link between aging and cancer.
The effort, outlined in a Development Cell paper published online today, aims to complement the ongoing Human Cell Atlas initiative, but with a focus on pediatric health.
In Genome Biology this week: analysis of wild and cultivated peach genomes, Hi-C-based pipeline for assembling microbial genomes from metagenomic data, and more.
The SciLifeLab spinout uses barcoded probes, in situ rolling circle amplification, and sequencing by ligation to measure expression of a panel of genes.
With single-cell RNA-seq on thousands of cells from the lateral hypothalamic area of male and female mice, researchers saw dozens of glutamatergic and GABAergic neuron types.
Analyzing mutational signatures in cancer cell lines and xenografts, investigators identified mutagenic processes that do or don't remain active in vitro.
