SILAC

In recently published work, the researchers combined RNA-seq, proteomics, and metabolomics to study mechanisms of action of the chemotherapeutic cisplatin.

Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research.

A team of Roche researchers has developed a five-plex SILAC method for quantifying the dynamics of tyrosine phosphorylation.

This story has been updated to correct an earlier version that identified Steven Gygi as an MIT researcher. He is a researcher at Harvard University.

A team led by researchers at the European Molecular Biology Laboratory has developed a new method for quantitative measurement of the secreted proteome, or secretome.

The screens, done independently by one Harvard-led and one MIT-led research team, both identified the protein Grb10 as an mTOR substrate and a likely tumor suppressor involved in regulating PI3K activity.

In particular, the study focused on signaling networks tied to CTL chromatin regulation with the aim of better understanding the systems of gene regulation characteristic of these cells, said one of the researchers.

The study showed that EGF signaling impacts ubiquitination across a wide range of protein networks and is one of the first to demonstrate cross-talk between ubiquitin-regulated and phospho-regulated signaling pathways, said one of the scientists.

Their study, Mann said, suggests that protein expression is more similar across cell types than previously thought — a finding with implications for drug development as well as basic cell biology research.

The collaboration, which aims to characterize the tryptic peptides of the 5,000 proteins in order to generate mass spectroscopy assays for them, brings together ISB's mass spectroscopy expertise and OriGene's extensive human protein collection.

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The ancestors of the Arizona bark scorpion and other scorpions and spiders underwent whole-genome duplication, KJZZ reports.

A cryptographic approach could help researchers keep genomic data private while researchers analyze it, Scientific American reports.

Andy Page, the former president of 23andMe, has joined a diabetes-management startup, according to CNBC.

In Cell this week: regulatory changes in pancreatic cancer, metabolic shifts in Alzheimer's disease, and more.