SILAC

Researchers have found genomic, transcriptomic, proteomic, and phenotypic variation in a comparison of HeLa cells across laboratories and over time.

This Week in Cell

In Cell this week: two waves of Denisovan-human mixing, open chromatin accessibility patterns during embryogenesis, and more.

In recently published work, the researchers combined RNA-seq, proteomics, and metabolomics to study mechanisms of action of the chemotherapeutic cisplatin.

Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research.

A team of Roche researchers has developed a five-plex SILAC method for quantifying the dynamics of tyrosine phosphorylation.

This story has been updated to correct an earlier version that identified Steven Gygi as an MIT researcher. He is a researcher at Harvard University.

A team led by researchers at the European Molecular Biology Laboratory has developed a new method for quantitative measurement of the secreted proteome, or secretome.

The screens, done independently by one Harvard-led and one MIT-led research team, both identified the protein Grb10 as an mTOR substrate and a likely tumor suppressor involved in regulating PI3K activity.

In particular, the study focused on signaling networks tied to CTL chromatin regulation with the aim of better understanding the systems of gene regulation characteristic of these cells, said one of the researchers.

The study showed that EGF signaling impacts ubiquitination across a wide range of protein networks and is one of the first to demonstrate cross-talk between ubiquitin-regulated and phospho-regulated signaling pathways, said one of the scientists.

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Customers might want to consider what they might learn about their risk of diseases like Alzheimer's before snagging the genetic testing kits that are on many gift guides this year, NJ.com writes.

The Wall Street Journal reports there is uncertainty surrounding whether He Jiankui's embryo editing did what he said it did.

Stat News reports that the pause on procuring fetal tissue for intramural US National Institutes of Health research will soon affect additional labs there.

In Nature this week: genomic analysis of the invasive fall webworm, amp of constrained coding regions within the human genome, and more.