shRNA

Researchers took two complementary approaches to assemble the Xenopus laevis genome — whole-genome and long-insert clone-based end sequencing.

Hairpin will be the exclusive agent for negotiating and executing new license agreements for patents covering the CSHL RNAi technology.

The scientists developed an algorithm to predict shRNA potency and a variant on the canonical microRNA scaffold for the RNAi molecules' construction.

Two members of Memorial Sloan-Kettering Cancer’s high-throughput drug screening facility this month published a study highlighting major shortcomings of RNAi screens, including the failure of such studies to yield reproducible hits.

Amid the continued advancement of biomedical research, it is becoming increasingly apparent that polytherapies — treatment regimens based on multiple drugs that address multiple aspects of a disorder — can offer superior efficacy to monotherapies.

Calimmune has become the latest RNAi drug developer to move into the clinic, recently initiating a phase I/II trial of its HIV therapy Cal-1.

While its primary focus remains on preparing its gene therapy for chronic heart failure for phase I testing, NanoCor Therapeutics is also aiming to advance an RNAi-based treatment for the condition.

Cold Spring Harbor Laboratory’s protracted legal battle against Ropes & Gray, a law firm that once served as the institution’s intellectual property counsel, was dismissed last week after the Massachusetts District Court hearing the case ruled that it did not have jurisdictio

Researchers from the University of Amsterdam this month reported new details in Nucleic Acids Research on how a particular shRNA configuration is processed through a Dicer-independent pathway while still maintaining RNAi properties, opening the door to a new shRNA design

Name:
Kevin Ryan
Position:
Associate professor, chemistry/biochemistry, City College of New York

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Researchers have treated an X-linked genetic disease affecting three babies in utero, Stat News reports.

The Associated Press reports that the US Centers for Disease Control and Prevention is beefing up sequencing as a tool to investigate foodborne illnesses.

Researchers have sequenced samples from ancient toilets to study past eating habits and health, NPR reports.

In Nature this week: ash dieback disease fungal genome, and more.