Sequencing Technology

If CareDx successfully commercializes its cfDNA tests, they would be the firm's first products since AlloMap launched in 2005.

The researchers described in a pre-print publication a modified sample prep process that enabled them to increase read lengths to over 100 kb.

The scientists combined whole-genome shotgun and fosmid pool sequencing, using next-generation sequencing technology from Illumina and BGI's Complete Genomics.

The partners will work on capturing circulating tumor cells for whole-genome sequencing and for use in mouse models for drug discovery and biomarker development.

Homozygous recessive mutations in the gene PRDM12 appear to contribute to congenital insensitivity to pain by interfering with sensory nerve development.

Methods and compositions for DNA fragmentation and tagging by transposases
Multibase delivery for long reads in sequencing by synthesis protocols
Determination of KIR haplotypes associated with disease
Methods and apparatus for detecting molecular interactions using FET arrays
Recombinant polymerases for improved single-molecule sequencing
Methods and apparatus for single-molecule sequencing using energy transfer detection

In PNAS this week: co-evolutionary signatures of insect hosts and bacterial symbionts, distinct transcript isoforms of high-grade ovarian cancer, and more.

Adam Rutherford discusses genetic genealogy at the Guardian.

Portions of the US 21st Century Cures Act are raising some safety concerns.

David Dobbs writes at Buzzfeed that genomics has delivered little on its promises.

May
28
Sponsored by
PerkinElmer

This online seminar will demonstrate how RNA-seq analysis in a model organism can provide insights into human disease. 

Jun
23
Sponsored by
PerkinElmer

This webinar will demonstrate how automated liquid handling workstations can reduce bottlenecks in library preparation for next-generation sequencing, enabling scientific advances in genomics research that were not possible five years ago.