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sequence capture

The new kits will enable researchers to measure expression levels of genes of interest rather than the entire genome, and to detect allele-specific expression, splice events, and gene fusions.

CEO Brooke Anderson said that the firm believes its sequence-capture approach will be more flexible and more affordable than offerings by established players in the target enrichment market, like Agilent, Roche NimbleGen, and RainDance.

Newcastle, UK-based NewGene will provide services for NimbleGen sequence capture arrays with next-generation sequencing on the Genome Sequencer FLX System from 454 Life Sciences.

The UK firm will provide services for NimbleGen Sequence Capture Arrays with sequencing on Roche 454's Genome Sequencer FLX System.

According to a company spokesperson, the growth was primarily driven across the two application areas by sales of its SeqCap EZ Exome offering for target enrichment as well as its CGX cytogenetic arrays.

While Agilent is contemplating offering the new content in an on-array format, the firm believes most customers will be served by its in-solution kit.

Besides SureSelect, SeqWright also uses NimbleGen Sequence Capture Arrays and RainDance Technologies' microdroplet PCR technology for target sequence enrichment.

The cuts were necessary to take advantage of a "window of opportunity" in miRNA discovery that could enable the firm to enter the molecular diagnostics market.

Both NimbleGen and Agilent are aware of the problem and are currently redesigning their capture products to include missing genes and improve the capture efficiency, according to a researcher affiliated with the evaluation project.

The firms will co-market RainDance's PCR-based sequence enrichment and Life Tech's SOLiD systems.


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