The researchers said their one-step, inducible, multiplex gene knockdown and gene knockout platforms can be used in many differentiated cell types.
The tool, developed by graduate student David Morgens, came from an attempt to translate bench science intuition into statistics and computer code.
The scientists found that combining results from each type of screen with a new statistical method improved results in finding essential genes.
In PLOS this week: sites in dog genome under selection during early domestication, tuberculosis transmission patterns, and more.
By comparing Cryptococcus genomes, Duke researchers found that C. deuterogattii lacks certain RNAi pathway genes, possibly contributing to its high virulence.
The patents broadly cover the use of small RNAs to trigger post-transcriptional gene silencing and are based on the work of Sainsbury Laboratory researchers.
The work could potentially make lab-based blood production cost-effective, as well as improve the creation of specific cell populations from stem cells.
RNAi might have fallen from favor, but it still holds promise, The Economist says.
The court found that the university had failed to demonstrate that one of its researchers had collaborated with the IP's inventors and therefore is not entitled to co-inventorship.
In Genome Research this week: regulation of alternative splicing events, host genetic-environment interactions' effect on mice gut microbes, and more.
The Associated Press reports that a state board in Texas has asked ANDE, a maker of rapid DNA machines, to halt its work there.
James Wyngaarden, the former director of the US National Institutes of Health, has died at 94, according to Duke University School of Medicine.
Researchers find that a 30-year-old skull comes from a narwhal-beluga hybrid, according to Science News.
In Nature this week: study of value diversity in GWAS, Epstein-Barr virus subtypes linked to nasopharyngeal carcinoma risk, and more.