The researchers said their one-step, inducible, multiplex gene knockdown and gene knockout platforms can be used in many differentiated cell types.
The tool, developed by graduate student David Morgens, came from an attempt to translate bench science intuition into statistics and computer code.
The scientists found that combining results from each type of screen with a new statistical method improved results in finding essential genes.
In PLOS this week: sites in dog genome under selection during early domestication, tuberculosis transmission patterns, and more.
By comparing Cryptococcus genomes, Duke researchers found that C. deuterogattii lacks certain RNAi pathway genes, possibly contributing to its high virulence.
The patents broadly cover the use of small RNAs to trigger post-transcriptional gene silencing and are based on the work of Sainsbury Laboratory researchers.
The work could potentially make lab-based blood production cost-effective, as well as improve the creation of specific cell populations from stem cells.
RNAi might have fallen from favor, but it still holds promise, The Economist says.
The court found that the university had failed to demonstrate that one of its researchers had collaborated with the IP's inventors and therefore is not entitled to co-inventorship.
In Genome Research this week: regulation of alternative splicing events, host genetic-environment interactions' effect on mice gut microbes, and more.
CBS This Morning highlights recent Medicare fraud involving offers of genetic testing.
Researchers find that many cancer drugs in development don't work quite how their developers thought they did, as Discover's D-brief blog reports.
Mariya Gabriel, a Bulgarian politician, is to be the next European Union research commissioner, according to Science.
In Science this week: a survey indicates that US adults are more likely to support the agricultural use of gene drives if they target non-native species and if they are limited, and more.