RNAi screen

Researchers from the Broad Institute and Novartis used RNA interference to generate catalogs of genes that cancer cells rely on to grow and survive.

The tool, developed by graduate student David Morgens, came from an attempt to translate bench science intuition into statistics and computer code.

The scientists found that combining results from each type of screen with a new statistical method improved results in finding essential genes.

The researchers combined CRISPR knockouts with RNAi screening to overcome key limitations in using the gene-silencing technology to identify new drug targets.

Researchers used RNA interference and automated trait analyses to systematically track phenotypes in Caenorhabditis elegans worms from two genetic backgrounds.

In the study, the scientists used RNAi screening, whole-exome sequencing, and affinity proteomics to identify genes involved in cilia formation, as well as disease-causing defects.

NEW YORK (GenomeWeb News) – Using genome-wide RNAi screens, Richard Youle at the US National Institute of Neurological Disorders and Stroke and his colleagues have identified a bevy of regulators of

NEW YORK (GenomeWeb News) – A genome-wide RNAi screen has turned up hundreds of potential drug targets for Huntington's disease, according to a paper published yesterday in PLoS Genetics.

By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) – Cytoo will coordinate a project announced on Monday that aims to combine high-throughput applications of RNAi with Cytoo's new cell normalization technology.

Using an RNA interference screen that relies on massively parallel sequencing, British researchers have identified new genes that seem to contribute to sensitivity or resistance to the breast cancer drug tamoxifen.

Pages

NPR reports that Turkish high school students will no longer study evolution.

Researchers report they sequenced and identified plant species in an "al fresco" laboratory.

An Australian team searches for genetic alterations linked to depression in hopes of developing personalized treatments, the Sydney Morning Herald reports.

In PNAS this week: host contributors to typhoid fever risk, effects of obesity-related variants near TMEM18, and more.