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RNA-seq

Researchers compared gene expression patterns in the brains of people with and without schizophrenia to uncover differences in when genes were expressed.

In Genome Biology this week: pipeline to analyze pan-genome collections, method to examine rare cell types, and more.

In Nucleic Acids Research this week: the hidden human proteome, single-cell-based expression signatures, and more.

An international team documented TP53 mutation-related genomic changes across dozens of cancer types using data generated with five platforms for the Cancer Genome Atlas project.

In Nature this week: new approach allows spatial characterization of microbial species, epigenetic research poised for clinical translation, and more.

The researchers also reported that their catalog of gene expression during cardiogenesis could help elucidate how birth defects develop.

Though some experts prefer the comprehensive nature of whole-genome sequencing, others find whole-exome sequencing or targeted exome panels to be more useful.

Re-expression of DUX4, which is normally silenced in somatic tissues, appeared to stymie MHC class I-related immune activity in several solid cancer types.

Using brain samples from individuals with or without multiple sclerosis, researchers detected declining projection neuron levels and related immune cell shifts.

Researchers characterized new and known cell populations with single-cell transcriptome profiles for nearly 10,400 liver cells, using the data to see changes associated with liver cancer.

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The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.