RNA-seq

A new set of papers reveals a range of gene expression influencers, identified using thousands of samples collected for the Genotype-Tissue Expression project.

With exome and/or RNA sequences for dozens of insulinomas, researchers saw epigenetic, development, and other pathways prompting insulin-producing cell expansion.

Lexogen has commercialized the method, which involves labeling newly synthesized RNA, and said it would have applications in drug discovery pipelines.

 

This Week in PNAS

In PNAS this week: transcriptional read-through in stressed cells, genome stability role for the epigenetic regulator CTCF, and more.

Hangzhou Chengyuan Genomics will provide single-cell analysis services and sell 1CellBio's InDrop instrument, reagents, and kits in China. 

Researchers plan to sequence 5,000 genomes and collect health and fitness data to tease out the role of genetics in things like aerobic capacity and bone density.

Investigators compared RNA sequence data in heart samples from individuals with dilated cardiomyopathy and samples from healthy transplant donor hearts.

A pair of studies has established a potential role for specific gut bacteria in the progression of MS, suggesting therapeutic targeting of the microbiota as a potential treatment.

This Week in PNAS

In PNAS this week: trait prediction algorithm, missense mutation linked to hearing loss, and more.

Genome and transcriptome sequences from hundreds of pediatric cancer cases led to somatic mutations and fusions suspected of producing potentially targetable antigens.

Pages

New Mexico is re-doing its proposed science education standards after criticism, the Associated Press reports.

Agbio executives say gene editing will speed up breeding efforts, according to the Wall Street Journal.

La Trobe University's Jenny Graves has won the $250,000 Prime Minister's Prize for Science, the Guardian reports.

In Cell this week: post-treatment changes to melanoma genome, multi-omics analysis of muscle-invasive bladder cancer, and more.