proximity ligation assay

In a talk at the meeting, Riken's Piero Carninci described the RADICL-seq tool he and his colleagues developed.

The firm has used its proximity ligation method to interpret metagenomic sequence data from a human fecal sample, unraveling new and known genomes in the mix. 

Combining PLA and mass cytometry, the method allows simultaneous measurement in the range of 40 to 50 RNAs and proteins in hundreds of thousands of cells.

PLA image

In a study, the method was able to detect the interaction of EGFR with an associated signaling protein and predict response to targeted therapies.

A team led by researchers at the University of Freiburg has developed a microfluidic chip for applying proximity ligation assays to cell signaling studies.

While Thermo Fisher Scientific's purchase of Life Technologies announced this week will no doubt have its greatest impact in the genomics and sequencing space, the deal has potential implications for proteomics, as well.

Researchers at the University of Virginia School of Medicine have devised a method based on Olink Bioscience's proximity ligation assay to observe histone modifications at specific gene loci in single cells.

A team from the University of Gothenburg working with Life Technologies has published a technique combining reverse transcription and proximity ligation to allow quantitative PCR measurements of the DNA, RNA, and proteins from a single cell.

A team led by researchers at the Kimmel Cancer Center at Thomas Jefferson University this week published a study in Cell suggesting that histone-modifying proteins such as histone methyltran

By Adam Bonislawski
With DNA-based affinity agents gaining prominence as tools for protein capture, scientists and biotech firms are exploring biomarker assays that simultaneously report both genetic and proteomic data.

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Cancer researcher Alan Rabson has died at 92, the New York Times reports.

As the National Guideline Clearinghouse goes dark, the ECRI Institute says it will pick up the slack.

In Genome Research this week: sequencing method examines proteins parasite uses to evade immune system, L1 insertions in cancer, and more.

The Atlantic reports on private Facebook support groups for people who receive unexpected parentage results from direct-to-consumer genetic tests.