proximity ligation assay

The VGP released its first 15 high-quality reference genome assemblies today, which are part of the project's first phase to sequence 260 vertebrate genomes.

In a talk at the meeting, Riken's Piero Carninci described the RADICL-seq tool he and his colleagues developed.

The firm has used its proximity ligation method to interpret metagenomic sequence data from a human fecal sample, unraveling new and known genomes in the mix. 

Combining PLA and mass cytometry, the method allows simultaneous measurement in the range of 40 to 50 RNAs and proteins in hundreds of thousands of cells.

PLA image

In a study, the method was able to detect the interaction of EGFR with an associated signaling protein and predict response to targeted therapies.

A team led by researchers at the University of Freiburg has developed a microfluidic chip for applying proximity ligation assays to cell signaling studies.

While Thermo Fisher Scientific's purchase of Life Technologies announced this week will no doubt have its greatest impact in the genomics and sequencing space, the deal has potential implications for proteomics, as well.

Researchers at the University of Virginia School of Medicine have devised a method based on Olink Bioscience's proximity ligation assay to observe histone modifications at specific gene loci in single cells.

A team from the University of Gothenburg working with Life Technologies has published a technique combining reverse transcription and proximity ligation to allow quantitative PCR measurements of the DNA, RNA, and proteins from a single cell.

A team led by researchers at the Kimmel Cancer Center at Thomas Jefferson University this week published a study in Cell suggesting that histone-modifying proteins such as histone methyltran

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The UK's Human Fertility and Embryology Authority calls for consumer genetic testing companies to warn customers that testing could uncover family secrets, according to the Guardian.

Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.

The New York Times reports that United Nations delegates have been discussing how to govern the genetic resources of the deep sea.

In PNAS this week: analysis of proteolytic enzymes secreted by circulating tumor cells, phylogenetic study of Fv1 evolution, and more.