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protein arrays

The company will explore the use of its UNIarray protein chip technology for the discovery of autoantibody patterns that are predictive of the disease.

When most people think of the array market, they might think of the whole-genome genotyping chips sold by firms like Affymetrix and Illumina. But for providers of array slides, printers, and scanners, the market increasingly is in protein chips, and business is good.

The Cambridge, Mass.-based firm will use its microarray technology to screen proteins for drug leads.

Protagen will focus on developing serum-based molecular diagnostic tests for early detection of multiple sclerosis and for differential diagnosis of prostate cancer.

The company will use the investments to develop its protein array for multiple sclerosis and prostate cancer.

The "carbon-on-metal" technology would address limitations to gold as a material for protein array development, making such arrays less susceptible to non-specific binding, less prone to denaturing proteins, and more reusable.

The Madison, Wis.-based company’s imaging systems analyze protein arrays made on gold biochips, which enables label-free analysis that may “accurately reflect how proteins function in real life,” the company said.

CEO Stefan Muellner told BioArray News last week that Protagen has shifted its business strategy from developing tests on its UniArray protein chip platform to discovering panels of biomarkers that can later be brought to market by bigger firms.

Funding Update for Jun 30, 2009

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Microarray-relevant NIH Grants Awarded in FY 2009, May 13 – June 22

Antigen Discovery retains rights to diagnostics related to the antigens.

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The American Prospect writes that the pilot program to test the DNA of migrants could lead to more family separations.

An international commission is to develop a report on how researchers, clinicians, and regulators should evaluate the clinical applications of human germline genome editing.

The US Department of Agriculture presents a new blueprint for animal genomic research.

In Genome Research this week: repetitive element deletion linked to altered methylation and more in form of muscular dystrophy; human contamination in draft bacterial and archaeal genomes; and more.