phylogenetic analysis

This Week in PNAS

In PNAS this week: influence of DNA architecture on genome editing, within-host HIV evolution, and more.

A phylogenetic analysis that included multiple samples per patient suggests overlapping driver mutations make their way into multiple metastases in each patient.

The researchers also reported that cholera strains infecting members of the same household were highly similar, suggesting in-household transmissions.

From infant skeletal remains going back hundreds of years, a team produced three Treponema pallidum genomes, representing both syphilis- and yaws-causing sub-species.

An analysis of 3,800-year-old Yersinia pestis isolates pushed the advent of flea-based plague transmission back to around 4,000 years ago, earlier than once proposed.

Researchers sequenced 61 Zika virus genomes isolated from patients in the region to reconstruct viral movements.

And Aren't Vulcan

A phylogenetic analysis of green-blooded lizards find the trait likely arose more than once, Reuters reports.

Up in the Trees

Researchers sequenced an ancient DNA from an extinct giant ground sloth to find it is a sister group to one group of modern sloths.

Sequencing has helped clarify the baleen whale family tree, though the researchers tell the New York Times it's more of a phylogenetic network.

Two studies have found that analyzing the timing of horizontal gene transfer events can help date microbial phylogenies.

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The UK's Human Fertility and Embryology Authority calls for consumer genetic testing companies to warn customers that testing could uncover family secrets, according to the Guardian.

The New York Times reports that United Nations delegates have been discussing how to govern the genetic resources of the deep sea.

Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.

In PNAS this week: analysis of proteolytic enzymes secreted by circulating tumor cells, phylogenetic study of Fv1 evolution, and more.