pharmacokinetics

The company's test, CNSDose, incorporates multiple genes involved in metabolism of antidepressants in the liver and how they cross into the brain via the blood-brain-barrier.

NEW YORK (GenomeWeb News) – Certara said this week that it is working with the Critical Path Institute, C-Path, to create a physiologically-based pharmacokinetic model of the human lung using Certara's Simcyp Population-based simulator software that will be used to test new tuberculosis drugs.

The US Food and Drug Administration this week released a new guidance that provides recommendations on when and how pharmaceutical companies and other investigators should consider genomic information in early-phase studies of a drug’s pharmacokinetics, pharmacodynamics, efficacy

The study will enroll patients with advanced liver cancers who are refractory to the standard of care, the company said.

The integration of ADMETRx's ADME evaluation and CeeTox's toxicity screening during drug discovery and lead optimization will help pharmaceutical and biotech companies efficiently improve their drug discovery decision making capabilities, a CeeTox official told CBA News.

The study findings suggest the genetic variations could eventually help researchers design more effective chemotherapeutic agents for pediatric ALL.

Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

Yale Environment 360 writes that synthetic and conservation biologists aren't always on the same wavelength, but they are trying to reach an understanding.

In Science this week: full CRISPR locus integration complex structure, and more.