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pharmacokinetics

The company's test, CNSDose, incorporates multiple genes involved in metabolism of antidepressants in the liver and how they cross into the brain via the blood-brain-barrier.

NEW YORK (GenomeWeb News) – Certara said this week that it is working with the Critical Path Institute, C-Path, to create a physiologically-based pharmacokinetic model of the human lung using Certara's Simcyp Population-based simulator software that will be used to test new tuberculosis drugs.

The US Food and Drug Administration this week released a new guidance that provides recommendations on when and how pharmaceutical companies and other investigators should consider genomic information in early-phase studies of a drug’s pharmacokinetics, pharmacodynamics, efficacy

The study will enroll patients with advanced liver cancers who are refractory to the standard of care, the company said.

The integration of ADMETRx's ADME evaluation and CeeTox's toxicity screening during drug discovery and lead optimization will help pharmaceutical and biotech companies efficiently improve their drug discovery decision making capabilities, a CeeTox official told CBA News.

The study findings suggest the genetic variations could eventually help researchers design more effective chemotherapeutic agents for pediatric ALL.

Nature News reports on the US National Science Foundation's investigations of undisclosed foreign ties among researchers it funds.

Researchers have developed a set of 10 principles to guide how a list of all species on earth should be put together, the Guardian reports.

Wired reports on a new firm developing a gene writing approach for therapeutic genome changes.

In Nature this week: a method called cis-X combines whole-genome and transcriptome sequencing data to identify regulatory noncoding variants, and more.