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non-coding sequences

Computational Tool Analyzes Noncoding Mutations to Classify Cancer Subtypes
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The tool, developed by Children's Hospital of Philadelphia, was able to establish distinct mutational patterns in five major pediatric cancers.

Glioblastoma Genomes Point to Non-Coding Driver Mutations

Researchers analyzed evolutionarily constrained non-coding mutations in genome sequences from dozens of glioblastoma patients, identifying regulation-related changes.

Multiple Myeloma Study Links More Than Three Dozen Genes to Disease

The researchers found that both coding and non-coding alterations drive the early development of multiple myeloma.

Noncoding Variants in Personal Genomes Reflect Medical Histories, Stanford Study Finds

A Stanford team found that variants in conserved binding sites reflect individuals' medical histories.

Search for Mutation-Sensitive Genome Sites Yields Tool for Finding Disease Players in Non-Coding Sequences

NEW YORK (GenomeWeb News) – By considering sequence data for individuals assessed through the 1000 Genomes Project, a team led by researchers from Yale University and Wellcome Trust Sanger Institute came up with a computational method for prioritizing potential disease culprits — including those
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The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.