non-coding sequences
The tool, developed by Children's Hospital of Philadelphia, was able to establish distinct mutational patterns in five major pediatric cancers.
Glioblastoma Genomes Point to Non-Coding Driver Mutations
Researchers analyzed evolutionarily constrained non-coding mutations in genome sequences from dozens of glioblastoma patients, identifying regulation-related changes.
Multiple Myeloma Study Links More Than Three Dozen Genes to Disease
The researchers found that both coding and non-coding alterations drive the early development of multiple myeloma.
Noncoding Variants in Personal Genomes Reflect Medical Histories, Stanford Study Finds
A Stanford team found that variants in conserved binding sites reflect individuals' medical histories.
Search for Mutation-Sensitive Genome Sites Yields Tool for Finding Disease Players in Non-Coding Sequences
NEW YORK (GenomeWeb News) – By considering sequence data for individuals assessed through the 1000 Genomes Project, a team led by researchers from Yale University and Wellcome Trust Sanger Institute came up with a computational method for prioritizing potential disease culprits — including those
May 5, 2010