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non-coding sequences

Computational Tool Analyzes Noncoding Mutations to Classify Cancer Subtypes
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The tool, developed by Children's Hospital of Philadelphia, was able to establish distinct mutational patterns in five major pediatric cancers.

Glioblastoma Genomes Point to Non-Coding Driver Mutations

Researchers analyzed evolutionarily constrained non-coding mutations in genome sequences from dozens of glioblastoma patients, identifying regulation-related changes.

Multiple Myeloma Study Links More Than Three Dozen Genes to Disease

The researchers found that both coding and non-coding alterations drive the early development of multiple myeloma.

Noncoding Variants in Personal Genomes Reflect Medical Histories, Stanford Study Finds

A Stanford team found that variants in conserved binding sites reflect individuals' medical histories.

Search for Mutation-Sensitive Genome Sites Yields Tool for Finding Disease Players in Non-Coding Sequences

NEW YORK (GenomeWeb News) – By considering sequence data for individuals assessed through the 1000 Genomes Project, a team led by researchers from Yale University and Wellcome Trust Sanger Institute came up with a computational method for prioritizing potential disease culprits — including those
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Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.