The new GeneEMBED computing method is generalizable to other polygenic diseases and "traits of interest," though it has only been tested on coding variants to date.
Tissue Network Analysis Points to Significant Sex-Related Regulatory Differences
Using Genotype-Tissue Expression project samples, researchers put together gene regulatory networks for 29 tissue types, uncovering extensive sex-related regulatory differences.
Cancer Susceptibility Contributions of Non-Coding SNPs Clarified With Network Approach
Using systems biology, investigators put cancer risk SNPs in a network context, identifying immune, tumor-related, and other genes influenced by the variants in multiple tissue types.
Heart Failure Regulatory Gene Revealed in Tissue Transcriptome Study
Using samples from heart failure patients and healthy controls, researchers uncovered a gene that, when absent in mice, reduced their risk of heart failure.
Integrated Blood Analysis Offers Look at Immune Development Over Infants' First Week
Researchers brought together blood transcriptomic, metabolomic, proteomic, and immune cell profiles for dozens of West African and Australasian infants.