nanopore

Syracuse University researchers have developed a nanopore-based technology that could enable detection of proteins in complex biological samples like serum.

The company had £13.8 million ($18.4 million) in revenues and a net loss of £56.6 million in 2017.

The company will use the funding to build a manufacturing facility, expand commercialization efforts, and develop new products.

Clive Brown, the company's chief technology officer, provided an update on the firm's business and talked about new products and planned improvements.

 

The system uses synthetic probes that bind to molecules of interest and then pass through solid-state nanopores, enabling detection of the target molecules.

The nanopore ZMW can enable lower starting amounts of DNA for PacBio sequencing, and may eventually enable direct RNA sequencing.  

The team showed in a study this week that they could detect BRAF mutations in thyroid cancer, and believe the method could also allow blood-based early cancer detection.

The company is working on both strand- and exonuclease-based nanopore sequencing as well as developing nanopore sensor technology.

The firm will scale up manufacturing of its nanopore sensor, expand its executive team, and push development of its sequencing and genome mapping applications.

UCSF will analyze Two Pore Guys' handheld nanopore device for its ability to detect a KRAS mutation from patient blood and urine samples.

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Researchers are refining a tool to predict a woman's risk of developing breast cancer, according to the Guardian.

According to Stat News, the partial government shutdown in the US could soon affect the ability of the Food and Drug Administration to review new drugs.

In PNAS this week: gypsy moth genome sequenced, phylogenomic analysis of Polyneopterans, and more.

CNN reports that people's genes tend to have a greater influence on their risk of developing disease than their environment, but it varies by phenotype.