mutation detection

Clustered mutation signatures in more than 1,000 tumors led to a process that appears to contribute to the development of some cancer driver mutations.

By sequencing the exomes of 25 sudden unexpected death syndrome cases from Thailand, investigators detected candidate mutations in 18 individuals.

Neon Therapeutics is sponsoring a Phase Ib trial of neoantigen-based vaccines in combination with anti-PD-1 treatment in melanoma, lung cancer, and bladder cancer.

Two independent research teams published findings for melanoma patients treated with vaccines developed against neo-antigens in their tumors that sequencing uncovered.

An international research team profiled more than 7,500 tumor genomes, including small-bowel adenocarcinoma, colorectal cancer, and gastric cancer genomes.

The Brown University spinout wants to apply its algorithms to help improve personalized cancer treatments.

KDSR mutations prevent skin from sealing in moisture and indicate that stimulating other pathways might help patients.

Researchers used exome and targeted sequencing to find alterations affecting KRAS and other cancer driver genes in a subset of deep infiltrating endometriosis samples.

Investigators identified new recurrently mutated genes and overlap with other histological endometrial cancer subtypes by profiling more than a dozen CCEC cases.

Rare mutations in the ANXA11 gene showed up in cases with familial and sporadic forms of amyotrophic lateral sclerosis.

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Researchers find that a personalized medicine approach could help people who experience pain while taking statins, New Scientist reports.

US National Science Foundation is continuing its responsible research conduct training policy despite its flaws, ScienceInsider reports.

A CRISPR-themed meeting explored how the tool could and should be used, Wired reports.

In Science this week: database of proteins' effects on cancer, targeted error correction sequencing, and more.